七叶皂苷钠治疗髌骨骨折术后软组织肿胀的疗效及对关节功能的影响

Efficacy of Sodium Aescinate on Soft Tissue Swelling after Patellar Fracture and Its Effects on Joint Function

目的:探讨七叶皂苷钠治疗髌骨骨折术后软组织肿胀的疗效及对关节功能的影响。方法:选取2015年7月至2018年6月承德医学院附属医院收治的髌骨骨折术后软组织肿胀患者74例作为研究对象,随机分为观察组和对照组,每组37例。2组患者均接受常规治疗,观察组在常规治疗的基础上应用七叶皂苷钠注射制剂。比较2组患者临床疗效;评估并比较2组患者治疗前后关节功能。结果:治疗后观察组疼痛、肿胀的总有效率显著高于对照组(72. 97%VS 62. 16%、54. 05%VS 48. 65%)。与治疗前比较,治疗后2组患者肿胀面积显著缩小,膝围值显著下降,HSS评分显著升高(P <0. 01),且2组间差异有统计学意义(P <0. 05或P <0. 01);观察组肿胀持续天数显著短于对照组(P <0. 01)。观察组药物性皮疹、静脉炎、静脉疼痛、血管条索状红肿等不良反应总发生率为16. 22%,与对照组的18. 92%并差异无统计学意义(P> 0. 05)。结论:七叶皂苷钠治疗髌骨骨折术后软组织肿胀对患者疼痛、肿胀的缓解效果更加显著,有效促进膝关节功能的康复,整体疗效突出。

Objective: To investigate the effects of sodium aescinate on soft tissue swelling after patellar fracture and its effects on joint function. Methods: A total of 74 patients with soft tissue swelling after patellar fracture in Affiliated Hospital of Chengde Medical College from July 2015 to June 2018 were selected and randomly divided into the observation group and the control group,with 37 cases in each group.The patients in 2 groups were treated with routine therapy.The observation group was treated with sodium aescinate injection on the basis of routine treatment.The clinical effects of 2 groups were compared,and the joint functions of 2 groups were evaluated and compared before and after treatment. Results: After treatment,the total effective rate of pain and swelling in the bservation group was significantly higher than that in control group (72.97% VS 62.16%,54.05% VS 48.65%).Compared with before treatment,the swelling area,knee circumference and HSS score of the 2 groups decreased significantly after treatment ( P <0.01),and there were significant differences between 2 groups ( P <0.05 or P <0.01);The duration of swelling in the observation group was significantly shorter than that in the control group ( P <0.01).The total incidence of drug rash,phlebitis,venous pain and vascular redness in the observation group was 16.22%,and there was no significant difference when compared with 18.92% in the control group ( P >0.05). Conclusion: The effect of sodium aescinate in the treatment of soft tissue swelling after patellar fracture was more significant in patients with pain and swelling,and it could promote the rehabilitation of knee joint function effectively,and the overall curative effect is outstanding.