化痰祛瘀方治疗痰湿犯肺型小儿慢性咳嗽的临床观察及对血清炎性因子的影响

Clinical Observation of Huatan Quyu Decoction on Chronic Cough of Phlegm-Dampness Invading Lung in Children and Its Effect on Serum Inflammatory Factors

目的:观察化痰祛瘀方对痰湿犯肺型小儿慢性咳嗽的临床疗效,并研究其对炎性因子的调节作用。方法:选取符合纳入标准95例慢性咳嗽患儿随机分为两组,对照组给予布地奈德气雾剂吸入治疗,观察组在对照组治疗的基础上采用化痰祛瘀方治疗。比较治疗前后两组患儿中医症候及体征积分、炎性因子水平、生活质量评价及临床疗效评价。结果:治疗后观察组IFN-γ水平较对照组显著升高(P<0.05),TNF-α、IL-4均较对照组显著降低(P<0.05);治疗后观察组患儿中医症候及体征积分均较对照组显著降低(P<0.05);观察组生理状况、心理健康、社会功能及总分较对照组显著升高(P<0.05);观察组总有效率91.7%(44/48),对照组总有效率72.3%(34/47),差异显著(P<0.05)。结论:化痰祛瘀方可以明显改善慢性咳嗽患儿的临床症状,具有较好的临床疗效,并且可以调节炎性因子水平。

Objective: To observe the clinical effect of Huatan Quyu Decotion on chronic cough of phlegm-dampness invading Lung in children, and to study its regulating effect on inflammatory factors. Methods: 95 children with chronic cough were randomly divided into the control group and the observation group. The control group was treated with Budesonide Aerosol Inhalation;on which basis, the observation group was also treated with Huatan Quyu Decoction. The scores of TCM symptoms and signs, levels of inflammatory factors, quality of life and clinical efficacy were compared before and after the treatment in the two groups. Results: After the treatment, the level of IFN-γ was significantly higher in the observation group than that in the control group( P <0.05). The levels of TNF-a and IL-4 were significantly lower in the observation group than those in the control group. The scores of TCM symptoms and signs were significantly lower in the observation group than those in the control group( P <0.05). The physiological status, mental health, social function and total scores were significantly higher in the observation group than those in the control group( P <0.05). The total effective rate was 91.7%(44/48) in the observation group, which was obviously higher than 72.3%(34/47) in the control group( P <0.05). Conclusion: Huatan Quyu Decoction can significantly improve the clinical symptoms of chronic cough in children, it has good clinical efficacy, and it can regulate the levels of inflammatory factors.