银屑病与HLA-DQ基因关联性的Meta分析

Association alleles study of HLA-DQ in psoriasis by Meta-analysis

目的基于Meta分析方法,了解银屑病的发病与HLA-DQ基因关联性。方法检索PubMed、ISI 1972年1月1日～2018年7月1日期间收录有关银屑病与HLA-DQ基因关联研究的相关SCI文献。结果共纳入文献16篇,样本总量6 075例(其中病例组2 944例),报道了51个HLA-DQ基因与银屑病存在关联。经过分析,共得到23个HLA-DQ基因与银屑病存在关联,11个HLA-DQ基因为银屑病的风险基因,12个HLA-DQ基因为银屑病的保护性基因,28个HLA-DQ基因与银屑病不存在关联。结论分析表明23个HLA-DQ基因与银屑病存在关联,且与种族、临床类型、发病年龄和家族史存在关联。

Objective Based on the Meta-analysis method,to clarify the association between psoriasis and HLA-DQ. Methods By search the PubMed and ISI Web of Knowledge databases,articles were selected from case–control studies on the association between psoriasis and HLA-DQ published from January 1,1972 to July 1,2018. Results 16 articles covering 6 075 participants (2 944 for case group) were included. Through Meta-analysis,51 HLA-DQ alleles were reported,among which 11 were associated with susceptibility to disease,12 were protective and 28 were unassociated. Conclusion A significant association was identified between psoriasis and 23 HLA-DQ alleles. The association varied in terms of race,clinical type,and onset age and family history of psoriasis.