超声遗传学技术中的机械敏感性离子通道

Application of mechanosensitive channels in sonogenetics

超声遗传学技术是一种非侵入性神经调控手段。机械敏感性离子通道可以被低强度的超声激活而开放,达到调节可兴奋性细胞活性的目的,避免高强度超声对组织器官可能造成的损害。本文着重介绍了大电导机械敏感性离子通道、瞬时受体电位通道、双孔钾通道、Piezo等机械敏感性离子通道在超声神经调控中的研究进展及其应用,以期为超声遗传学研究提供参考。

As a non-invasive approach,sonogenetics is applied to control neuronal activity.The mechanosensitive channel(MSC),which has low threshold of responding to ultrasound,may be the alternative solution.Sonogenetics is the technique that activates the MSC expressed in targeted neurons by low intensity ultrasound,thus achieve the neuromodulation.In this review,we introduce the mechanosensitive channel of large conductance,transient receptor potential,channels of the two-pore-domain potassium family,Piezo and the recent progress on their application in sonogenetics.