外泌体参与卵巢癌患者对化疗耐药的研究进展

Research advances on the role of exosomes in chemotherapy resistance of ovarian cancer

患者对化疗药物耐药是晚期卵巢癌患者治疗失败的主要原因之一。外泌体可能通过作为细胞排出化疗药物的途径、通过其携带耐药相关核酸、蛋白质等内容物及通过中和抗体类药物等方式促进卵巢癌患者对化疗药物耐药的发生和发展。本文阐述了外泌体与卵巢癌患者对化疗药物耐药的相关性、外泌体参与耐药的作用机制及其临床价值,以期为卵巢癌患者对化疗药物耐药机制研究、临床诊断和干预提供新的思路。

Chemotherapy resistance is one of the biggest challenges in treatment of ovarian cancer.Mounting evidence shows that the exosomes shedding from tumor cells are considered to be involved in chemotherapy resistance of ovarian cancer by enhanced exosomal export of drugs,transferring RNAs or proteins and interfering with the bioactivity of therapeutic anti-tumor antibodies.In this review,we display the correlation between exosomes and chemotherapy resistance of ovarian cancer,the mechanism of exosomes involved in chemotherapy resistance of ovarian cancer,and discuss the potential clinical values of exosomes in chemotherapy resistance of ovarian cancer.