泮托拉唑治疗胃十二指肠溃疡的临床效果及其对胃Hp的影响研究

Effect of pantoprazole on gastric duodenal ulcer and its effect on gastric Hp

目的探讨泮托拉唑治疗胃十二指肠溃疡的效果及其对胃Hp的影响。方法本次研究选择本院2015年1月至2016年12月收治的胃十二指肠溃疡患者60例,随机分组,各组30例,两组患者均按照常规进行治疗,包括纠正患者紊乱的水电解质状态,给予营养补充,改善患者的营养状况,对胃出血患者进行输血治疗。对照组给予奥美拉唑口服治疗;观察组在常规治疗与奥美拉唑前提下,加入泮托拉唑口服治疗。比较两组患者Hp治疗效果、胃十二指肠溃疡愈合效果、胃液pH值变化、胃Hp根除率、不良反应。结果①观察组Hp疗效(93.33%)较对照组(50%)明显更高,差异有统计学意义(P<0.05)。②观察组胃溃疡愈合率(90%)较对照组(60%)明显更高,组间差异有统计学意义(P<0.05)。③观察组不良反应发生率(10%)明显较对照组(26.67%)更低,差异有统计学意义(P<0.05)。④和治疗前对比,两组患者治疗后24h和治疗后48h胃液pH明显恢复,差异有统计学意义(P<0.05);组间对比,观察组治疗后胃液pH明显比对照组更高,差异有统计学意义(P<0.05)。⑤和对照组(60.00%)对比,观察组Hb根除率(93.33%)明显更高,差异有统计学意义(P<0.05)。结论泮托拉唑治疗胃十二指肠溃疡的效果明显,可加快降低胃Hp,从而根治胃十二指肠溃疡的病灶,同时不良反应较少,安全可靠。

Objective To investigate the effect of pantoprazole in the treatment of gastroduodenal ulcer and its effect on gastric Hp. Methods This study choose our hospital between January 2015 and December 2015, 60 patients with gastric duodenal ulcer treated, random grouping, each group 30 cases, two groups of patients were carried out in accordance with the conventional treatment, including correcting the disorder of water electrolyte status, nutritional supplement, improve the nutritional status of patients, blood transfusion therapy in patients with stomach bleeding. The control group was given omeprazole orally. In the observation group, on the premise of conventional treatment and omeprazole, oral treatment with pantoprazole was added. The therapeutic effect of Hp, healing effect of gastroduodenal ulcer, PH value of gastric juice, eradication rate of gastric Hp and adverse reactions were compared between the two groups. Results ①The efficacy of Hp in the observation group (93.33%) was significantly higher than that in the control group (50%), and the difference was statistically significant (P<0.05).②The healing rate of gastric ulcer in the observation group (90%) was significantly higher than that in the control group (60%), and the difference was statistically significant (P<0.05).③The incidence of adverse reactions in the observation group (10%) was significantly lower than that in the control group (26.67%), and the difference was statistically significant (P<0.05).④And the comparison before treatment, two groups of patients after treatment 24h and 48h after treatment of gastric juice PH obvious recovery, the difference was statistically significant (P<0.05);After treatment, the PH of gastric juice in the observation group was significantly higher than that in the control group (P<0.05).⑤Compared with the control group (60.00%), the eradication rate of Hb in the observation group (93.33%) was significantly higher, and the difference was statistically significant (P<0.05). Conclusion Pantoprazole has obvious effect in the treatment of gastroduodenal ulcer, which can accelerate the reduction of gastric Hp and thus cure the lesions of gastroduodenal ulcer. At the same time, it has fewer adverse reactions and is safe and reliable.