抗生素肝素混合液在血液透析患者留置导管封管的效果研究

Effect of antibiotic heparin mixture on indwelling catheter sealing in hemodialysis patients

目的研究分析血液透析患者采用抗生素肝素混合液对留置导管封管的临床效果。方法选取2015年11月至2017年11月本院接受血液透析治疗的88例患者为此次研究对象,按照数字表随机分为研究组和参照组,其中参照组44例,采用单一肝素封管,研究组44例,予以抗生素以及肝素混合封管,比较两组不同时间段的HCRI发生情况以及血栓发生情况。结果研究组治疗6个月、12个月的HCRI发生率分别为(4.54%)、(6.81%),与参照组治疗6个月、12个月的HCRI发生率(6.81%)、(11.36%),比较差异无统计学意义;治疗24个月后,研究组HCRI发生率为(11.36%),与参照组HCRI发生率(29.54%)比较差异有统计学意义(P<0.05);同时治疗6个月、12个月以及24个月,研究组血栓发生率分别为(2.27%)、(6.81%)、(15.90%),均低于参照组血栓发生率(4.54%)、(13.63%)、(20.45%),但组间比较差异无统计学意义。结论对血液透析患者实施抗生素肝素混合液封管,具有一定的应用安全性,值得临床推广。

Objective To study and analyze the clinical effect of hemodialysis patients on indwelling catheter sealing by using heparin mixture of antibiotics. Methods Selection in November 2015 to November 2017, 88 cases of hemodialysis treatment in our patients as the research object, in accordance with the principle of digital meter randomized, divided into research group and control group, the control group of 44 cases, using single heparin sealing tube, the team for the 44 cases, antibiotics and heparin mixing tube, compared two groups of different periods of HCRI occurrence happening and blood clots. Results The incidence of HCRI in the study group at 6 months and 12 months was (4.54%) and (6.81%), respectively. The incidence of HCRI (6.81%) and (11.36%) at 6 months and 12 months after treatment with the reference group. The difference was not statistically significant. After 24 months of treatment, the incidence of HCRI in the study group was 11.36%, which was statistically significant compared with the incidence of HCRI in the reference group (29.54%)(P<0.05). At the months, 12 months, and 24 months, the incidence of thrombosis in the study group was (2.27%),(6.81%), and (15.90%), respectively, which were lower than the thrombosis rate of the reference group (4.54%),(13.63%).(20.45%), but the difference between the groups was not statistically significant. Conclusion It is safe for hemodialysis patients to seal up the hemodialysis with antibiotic heparin mixture.