植物SPFH超家族蛋白及其生物学功能研究进展

Recent advances on SPFH superfamily proteins and their biological functions in plants

膜微区(membrane microdomains)是细胞质膜上富含固醇类和鞘脂类的微结构域,大小为10~200 nm,为一种高度动态的结构。膜微区富含多种标记蛋白,例如GPI(glycosylphosphatidylinositol)锚定蛋白和许多膜整合蛋白。其中SPFH超家族蛋白(Stomatin、Prohibitin、Flotillin and Hflk/C)进化保守,并且广泛分布于原核和真核生物中。研究表明SPFH蛋白具有多种重要的生物学功能,参与植物的抗病、抗逆和生长发育等过程,因此受到了越来越多的关注。本文主要介绍了SPFH超家族蛋白的结构及其寡聚化状态,且进一步综述了SPFH超家族蛋白在植物中的研究进展,以期为今后系统开展其在膜微区形成过程中的功能研究提供理论依据。

Membrane microdomains are nano-scale domains (10-200 nm) enriched in sterols and sphingolipids. They are small and highly dynamic to host glycosylphosphatidylinositol (GPI)-anchored proteins and a subset of cell surface proteins. Among them, the SPFH domain-containing proteins (Stomatin, Prohibitin, Flotillin and HIR) are evolutionary conserved and present in both prokaryotes and eukaryotes. Recently, more and more evidences support the conclusion that SPFH superfamily proteins play important roles in response to biotic and abiotic stresses. Therefore, this review focuses on the structures and oligomerization of SPFH domain family proteins, with special emphasis on recent progresses in biological functions of these proteins in plants, which will provide valuable information for further studies on SPFH proteins in the formation of membrane microdomains.