烧伤创疡再生医疗技术治疗眼镜蛇咬伤疗效观察

Observation on the Clinical Efficacy of MEBT/MEBO in the Treatment of Cobra Bite

目的对比观察烧伤创疡再生医疗技术治疗眼镜蛇咬伤创面的临床疗效。方法将2010年6月至2016年6月福建中医药大学附属人民医院收治的120例眼镜蛇咬伤致局部皮肤出现灰黑斑的患者随机分为治疗组(60例)与对照组(60例),其中治疗组患者采用烧伤创疡再生医疗技术治疗局部创面,对照组患者采用重组牛碱性成纤维细胞生长因子凝胶(贝复新)治疗局部创面,对比观察两组患者的创面愈合情况。结果治疗30d时,治疗组患者的总有效率为70.00%,对照组患者的总有效率为51.67%,两组对比,P<0.05,差异具有统计学意义;治疗60 d时,治疗组患者的总有效率为96.67%,对照组患者的总有效率为86.67%,两组对比,P<0.05,差异具有统计学意义;最终两组患者创面均完全愈合,其中治疗组患者创面愈合时间为(43.63±20.48)d,对照组患者创面愈合时间为(66.93±36.45)d,两组对比,P<0.05,差异具有统计学意义。结论烧伤创疡再生医疗技术治疗眼镜蛇咬伤创面,可有效促进创面愈合,缩短创面愈合时间,疗效明显优于贝复新,值得临床推广应用。

Objective To observe the clinical efficacy of MEBT/MEBO in the treatment of cobra bite.Methods 120 patients with gray black skin spots caused by cobra bites,admitted to The Affiliated People’s Hospital of Fujian University of Traditional Chinese Medicine between June 2010 and June 2016,were randomly divided into a treatment group(60 cases)and a control group(60 cases).The patients in the treatment group were treated with MEBT/MEBO locally whereas the patients in the control group were treated with the recombined bovine basic fibroblast growth factor(bFGF)gel locally.The wound healing condition was observed and compared between the two groups.Results After 30 days of treatment,the total effective rate was 70.00%in the treatment group and 51.67%in the control group,between which the comparison showed statistically significant difference(P<0.05).After 60 days of treatment,the total effective rate was96.67%in the treatment group and 86.67%in the control group,between which the comparison also showed statistically significant difference(P<0.05).At the end,the wounds of patients were all completely healed in both groups.The wound healing time was(43.63±20.48)d in the treatment group,which showed statistically significant difference as compared with(66.93±36.45)d in the control group(P<0.05).Conclusion In the treatment of cobra bites,the clinical efficacy of MEBT/MEBO is obviously superior to that of bFGF,including effectively promoting wound healing and shortening the wound healing time,deserving to be promoted in clinical practice.