胆道闭锁发生与肝纤维化的分子机制研究进展

Advances in molecular mechanisms of biliary atresia and hepatic fibrosis

胆道闭锁(biliary atresia,BA)的典型表现为肝内外胆管持续性炎症和迅速进展的肝纤维化,目前国内外对于胆道闭锁的病因尚无定论。因此,本文通过查阅、分析、总结近10年来的胆道闭锁相关文献,对胆道闭锁发生及其致肝纤维化的分子机制研究进展作一综述。

Biliary atresia(BA)is characterized by persistent internal and external inflammation of bile duct of liver with a rapid progress of liver fibrosis.Today the cause of BS has remained elusive.The occurrence of BS is so complex that various factors play important roles.This review has summarized the relevant literature reports over the last decade.The occurring mechanism,its relationship with various factors and development trends are thoroughly reviewed.