血液灌流在急性中毒患者的应用效果及对炎症因子影响

Effect of Hemoperfusion on Patients with Acute Poisoning and Its Influence on Inflammatory Factors

目的:分析急性中毒患者救治过程中血液灌流的应用效果及对炎症因子的影响。方法:选取2015年1月-2018年1月笔者所在医院收治的急性中毒患者90例,所有患者均接受血液灌流治疗,分析其治疗效果。结果:90例急性中毒患者行血液灌流治疗后,82例患者康复出院,8例患者死亡,成功救治率为91.11%。治疗后患者IL-8、IL-6、TNF-α水平均低于治疗前,差异均有统计学意义(t=9.61、11.18、10.27,P<0.05)。血液灌流开始时、血液灌流120 min时患者血钠、血钾、碳酸氢根、CO2分压水平对比差异无统计学意义(t=0.95、0.09、0.68、0.51,P>0.05);与血液灌流开始时相比,血液灌流120 min时的血糖、乳酸水平均有所降低,氧分压有所提高,差异均有统计学意义(t=4.93、6.28、7.54,P<0.05)。结论:急性中毒患者救治过程中血液灌流的应用效果显著,能改善机体炎症水平,可将其广泛推广。

Objective:To analyze the application effect of blood perfusion and the effect on inflammatory factors in the treatment of acute poisoning patients.Method:From January 2015 to January 2018,90 patients with acute poisoning admitted to our hospital were selected.All patients underwent blood perfusion therapy and analyzed their therapeutic effects.Result:After hemoperfusion therapy,82 patients recovered and discharged,8 patients died.The successful treatment rate was 91.11%.The levels of IL-8,IL-6,TNF-α in patients after treatment were significantly lower than those before treatment(t=9.61,11.18,10.27,P<0.05).At the beginning of hemoperfusion,there was no significant difference in serum sodium,potassium,bicarbonate and CO2 partial pressure at 120 min after hemoperfusion(t=0.95,0.09,0.68,0.51,P>0.05).Compared with that at the beginning of hemoperfusion,the blood glucose,lactic acid level and partial pressure of oxygen increased at 120 min after hemoperfusion(t= 4.93,6.28,7.54,P<0.05).Conclusion:The application of blood perfusion in the treatment of acute poisoning patients is significant,which can improve the level of inflammation in the body and it can be widely promoted.