系统性硬化症与肠道菌群的关系

Intestinal Microbiota in Systemic Sclerosis

肠道菌群对人类健康和疾病有着深远影响。不仅肠道菌群能影响宿主免疫系统发育,免疫系统本身也能改变肠道菌群。目前发现肠道菌群参与了多种自身免疫性疾病。研究发现,系统性硬化症(systemic sclerosis,SSc)患者肠道菌群紊乱较常见,胃肠道易受累,且其中一些特定菌属与SSc患者胃肠道受累严重程度相关。本文对SSc患者肠道菌群变化特点、肠道菌群与SSc消化系统运动障碍和纤维化的关系以及治疗方案等方面进行系统阐述。

The intestinal microbiota has a profound effect on human health and diseases. It affects the development of the immune system of the host and vice versa. At present, the intestinal microbiota has been found to be involved in many autoimmune diseases. Gastrointestinal tract involvement is common in patients with systemic sclerosis (SSc). Studies found that the gastric and intestinal flora of SSc patients are in disorder, and some of the specific bacteria are related to the severity of gastrointestinal involvement in SSc patients. In this paper, the related research on the intestinal flora of SSc was reviewed,such as changes in intestinal flora, the relationship between the intestinal flora and dyskinesia and fibrosis of the digestive system, and the progress of treatment.