巨噬细胞参与系统性硬化症发病机制的研究进展

Macrophage Involvement and Its Pathogenesis in Systemic Sclerosis

纤维化是系统性硬化症的主要病理改变,具体机制尚不明确。巨噬细胞在体内通过多种途径参与系统性硬化症的发生发展,其作用不可忽视。近年来巨噬细胞与该疾病的研究报道多集中于巨噬细胞极化、活化等调节作用及其相关标志物方面,另外还涉及巨噬细胞与其他免疫细胞、Toll样受体的关系等。本文就上述几方面,总结了巨噬细胞在系统性硬化症发病机制中的研究进展。

Fibrosis is the characteristic hallmark of systemic sclerosis (SSc). Although the specific mechanism has been unknown, the role of macrophages in the development of this complex disease through various ways cannot be negligible. Findings during the past 5 years have contributed to more understanding of the relationship between macrophages and SSc. This review is mainly about the progress of research on macrophages in SSc. We discuss whether or not macrophages skew toward the M1-like phenotype from the profibrotic M2-like phenotype. Some biomarkers are also listed. In addition, we elaborate on the association of macrophages with other immune cells and Tall-like receptors.