抗凝联合降血脂治疗糖尿病动脉粥样硬化的效果观察

Therapeutic Effect of Anticoagulation Combined with Hypolipidemic Therapy on Diabetic Atherosclerosis

目的:探索抗凝治疗联合降血脂治疗用于糖尿病动脉粥样硬化患者的效果。方法:在笔者所在医院2017年1月-2018年5月收治的糖尿病合并动脉粥样硬化患者中选出134例为研究对象,随机分为两组,对照组患者给予常规对症治疗和抗凝治疗,观察组患者在对照组治疗措施基础上给予降血脂治疗。对比两组患者的血糖水平、血脂水平、斑块厚度等。结果:治疗6个月后,观察组患者的空腹血糖(FBG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、胰岛素抵抗指数(HOMA-IRI)、颈动脉内膜中层厚度、斑块厚度、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平均低于对照组,差异均有统计学意义(P<0.05);观察组患者高密度脂蛋白胆固醇(HDL-C)水平高于对照组,差异有统计学意义(P<0.05);观察组并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:抗凝联合他汀类药物降血脂治疗有助于促进糖尿病动脉粥样硬化患者血糖、血脂指标的控制,稳定斑块,减少糖尿病并发症发生,提高患者生活质量,值得推广应用。

Objective:To explore the effect of anticoagulation therapy combined with hypolipidemic therapy in patients with diabetic atherosclerosis.Method:A total of 134 patients with diabetes and atherosclerosis admitted to our hospital from January 2017 to May 2018,and they were randomly divided into two groups.Patients in the control group were given routine symptomatic treatment and anticoagulation therapy.Patients in the observation group were given hypolipidemic treatment on the basis of treatment measures in the control group.Blood sugar level,blood lipid level and plaque thickness were compared between the two groups.Result:After 6 months of treatment,the fasting blood sugar(FBG),fasting insulin(FINS),glycated hemoglobin(HbA1c),insulin resistance index(HOMA-IRI),carotid intima-media thickness,plaque thickness,the levels of total cholesterol(TC),triglyceride(TG)and low density lipoprotein cholesterol(LDL-C)of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05),and the levels of high density lipoprotein cholesterol(HDL-C)in the observation group was higher than those of the control group,the difference was statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,the difference was statistically significant(P<0.05).Conclusion:Anticoagulation combined with Statin drugs to reduce blood lipids can promote the control of blood sugar and blood lipids in patients with diabetes atherosclerosis,stabilize plaque,reduce the incidence of diabetes complications,improve the quality of life of patients,and it is worthy of popularization and application.