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孟鲁司特钠治疗小儿咳嗽变异性哮喘效果评价 被引量:5

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摘要 目的:探究对小儿咳嗽变异性哮喘(cough variant asthma,CVA)患儿实施孟鲁司特钠治疗的效果。方法:选取2016年4月-2018年2月笔者所在医院126例小儿咳嗽变异性哮喘患儿为研究对象,随机分为观察组(63例,应用常规治疗+孟鲁司特钠治疗)和对照组(63例,应用常规治疗)。对比两组患儿的疗效、肺功能指标、咳嗽缓解时间、咳嗽消失时间、炎症因子水平、不良反应发生率及复发率。结果:(1)观察组治疗总有效率为92.06%,高于对照组的76.19%,差异有统计学意义(P<0.05);(2)观察组患儿治疗后FEV1、FVC、FEV1/FVC均高于对照组,差异均有统计学意义(P<0.05);(3)观察组治疗后IL-6、TNF-α均低于对照组,但IL-12高于对照组,差异均有统计学意义(P<0.05);(4)观察组咳嗽缓解时间、咳嗽消失时间均短于对照组,差异均有统计学意义(P<0.05);(5)观察组复发率为1.59%,低于对照组的11.11%,差异有统计学意义(P<0.05),两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对小儿咳嗽变异性哮喘患儿实施孟鲁司特钠治疗十分可行,效果较佳,有助于减少复发。
作者 李名荣
机构地区 黄石市第五医院
出处 《中外医学研究》 2019年第13期149-151,共3页 CHINESE AND FOREIGN MEDICAL RESEARCH
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