奥美拉唑镁肠溶片与去甲肾上腺素联合用于治疗脑血管病应激性溃疡的临床观察

Clinical Observation of Combination of Omeprazole Magnesium Enteric-coated Tablets and Norepinephrine in the Treatment of Stress Ulcer of Cerebrovascular Disease

目的:探析对脑血管病应激性溃疡患者采用奥美拉唑镁肠溶片与去甲肾上腺素联合治疗的效果及安全性。方法:选取笔者所在医院于2016年9月-2018年5月收治的72例脑血管病应激性溃疡患者,将其随机分为对照组与观察组,各36例。其中对照组采取单一奥美拉唑镁肠溶片的治疗方式,观察组则进行奥美拉唑镁肠溶片联合去甲肾上腺素的治疗方式。之后对比两组患者治疗前后胃液p H值的改善情况、临床症状缓解情况及临床疗效。结果:观察组的临床治疗总有效率达94.4%,对照组临床治疗总有效率仅为72.2%,差异有统计学意义(P<0.05);两组患者治疗前胃液pH值差异无统计学意义(P>0.05),观察组经治疗后,胃液pH值改善情况显著优于对照组;且观察组溃疡疼痛缓解效率显著优于对照组,两组相比差异有统计学意义(P<0.05)。结论:脑血管病应激性溃疡的治疗过程中,给予患者奥美拉唑镁肠溶片联合去甲肾上腺素的治疗方式,可显著提升患者的临床疗效,改善其胃液pH值,促进患者的临床症状缓解效率,值得推广借鉴。

Objective:To explore the efficacy and safety of combined therapy of Omeprazole Magnesium Enteric-coated Tablets and Norepinephrine in patients with stress ulcer of cerebrovascular disease.Method:From September 2016 to May 2018,72 patients with stress ulcer of cerebrovascular disease in our hospital were randomly divided into the control group and the observation group,with 36 cases in each group.The control group was treated with a single Omeprazole Magnesium Enteric-coated Tablets,while the observation group with Norepinephrine and Omeprazole Magnesium Enteric-coated Tablets.After that,the improvement of gastric juice pH,the relief of clinical symptoms and the clinical efficacy were compared between the two groups before and after treatment.Result:The total effective rate of clinical treatment in the observation group was 94.4%,while that of the control group was 72.2%,there was significant difference in two groups(P<0.05).There was no significant difference in pH value of gastric juice between the two groups before treatment.The improvement of pH value of gastric juice in the observation group was significantly better than that in the control group after treatment(P<0.05).The relief rate of ulcer pain in the observation group was significantly higher than that in the control group,and the difference between the two groups was significant(P<0.05).Conclusion:During the treatment of stress ulcer of cerebrovascular disease,the treatment of Omeprazole Magnesium Enteric-coated Tablets combined with Norepinephrine can significantly improve the clinical efficacy and improve the pH value of gastric juice.In order to promote the clinical symptom relief efficiency of patients,it is worth popularizing.