奥曲肽联合奥美拉唑治疗肝硬化合并上消化道出血的效果

Curative Observation of Octreotide Combined with Omeprazole on the Treatment of Liver Cirrhosis with Upper Gastrointestinal Bleeding

目的:观察奥曲肽联合奥美拉唑治疗肝硬化合并上消化道出血的临床效果。方法:70例肝硬化合并上消化道出血患者根据止血药物选择不同分为两组,两组患者均予以对症支持治疗,对照组(35例)在此基础上加用垂体后叶素联合奥美拉唑治疗,观察组(35例)则加用奥曲肽联合奥美拉唑治疗,两组患者治疗时间均为1周。比较两组患者治疗总有效率、住院治疗时间、止血时间、再出血率及治疗期间出现的心悸、心律失常、恶心呕吐、胃肠道痉挛等不良反应发生率。结果:观察组患者治疗总有效率(88.57%)明显高于对照组(68.57%),差异有统计学意义(P<0.05);观察组住院治疗时间明显少于对照组(P<0.05),止血时间明显快于对照组(P<0.05),且再出血率明显低于对照组(P<0.05);观察组患者心悸、心律失常、恶心呕吐、胃肠道痉挛等不良反应发生率(8.57%)明显低于对照组(28.57%),差异有统计学意义(P<0.05)。结论:奥曲肽联合奥美拉唑治疗肝硬化合并上消化道出血效果显著,可明显缩短住院治疗时间和止血时间,降低再出血率及不良反应发生率。

Objective:To observe the clinical effect of Octreotide combined with Omeprazole on the treatment of liver cirrhosis with upper gastrointestinal bleeding.Method:A total of 70 patients with liver cirrhosis with upper gastrointestinal bleeding were divided into two groups according to the different choice of hemostatic drugs.Both groups were treated by symptomatic support treatment.The control group(35 cases)was treated with Pituitrin combined with Omeprazole on this basis.The observation group(35 cases)was treated with Octreotide combined with Omeprazole.The treatment time of two groups were all one week.The total effective rate,hospitalization time,hemostasis time,rebleeding rate and adverse reactions such as palpitation,arrhythmia,nausea and vomiting,gastrointestinal spasm during treatment of the two groups were compared.Result:The total effective rate(88.57%)of the observation group was significantly higher than 68.57%of the control group(P<0.05).The hospitalization time of the observation group was significantly shorter than that of the control group(P<0.05),the hemostasis time was significantly faster than that of the control group(P<0.05),and the rebleeding rate was significantly lower than that of the control group(P<0.05).The incidence of adverse reactions such as palpitation,arrhythmia,nausea and vomiting,gastrointestinal spasm of the observation group(8.57%)were significantly lower than 28.57%of the control group(P<0.05).Conclusion:The treatment of Octreotide combined with Omeprazole for the liver cirrhosis with upper gastrointestinal bleeding has a significant effect,which can significantly shorten the hospitalization time and hemostasis time,reduce the rate of re-bleeding and the incidence of adverse reactions.