孕前优生遗传咨询与检查的临床意义

Clinical Significance of Genetic Counseling and Examination of Pregestational Eugenics

目的探析备孕夫妇进行孕前优生遗传咨询与检查的价值及意义。方法选取我院于2016年1月—2018年12月来院接受孕前咨询的900对备孕夫妇,对其孕前优生咨询与检查的临床意义进行深入的研究探讨。结果900对遗传中心检查夫妇中共有816对夫妇接受了孕前优生遗传检查,总检查率为90.7%;2018年我院优生遗传中心的优生遗传咨询夫妇有326对,共有318对接受检查,检查率为97.5%;2017年优生遗传中心的优生咨询夫妇有310对,共有276对接受检查,检查率为89.0%;2016年优生遗传中心的优生咨询夫妇有264对,共有222对接受检查,检查率为84.1%,其中2018年检查率显著高于2017年和2016年,差异有统计学意义(P<0.05);816对夫妇接受检查后成功受孕,其中检出87例为高危产妇,占比10.7%;之后对这87例高危产妇进行四维彩超筛查出2例胎儿为先天性缺陷儿,占比2.29%。结论优生咨询与检查是作为孕前保健一项不可避免的重要措施,它可有效降低缺陷儿的出生率,提高产妇的生殖健康水平与人口素质。

Objective To explore the value and significance of genetic counseling and examination for pregnant couples.Methods 900 pregnant couples who received pre-pregnancy counseling and examination in our hospital from January 2016 to December 2018 were selected,and the clinical significance of pre-pregnancy counseling and examination was studied.Results 900 couples were examined by the genetic center,816 couples were examined by genetic center before pregnancy,the total examination rate was 90.7%.In 2018,there were 326 eugenic genetic counseling couples at eugenic genetic center in our hospital,a total of 318 couples were examined,and the examination rate was 97.5%.In 2017,there were 310 eugenic counseling couples at the eugenic genetic center,276 of whom were examined,the examination rate of 89.0%;In 2016,There were 264 eugenic counseling couples in the eugenic genetic center,and 222 couples were examined,the examination rate was 84.1%,the examination rate in 2018 was significantly higher than 2017 and 2016,the difference was statistically significant(P<0.05).816 couples successfully conceived after being examined,Among them,87 cases were found to be high risk women,accounting for 10.7%,the 87 high-risk women were screened by four-dimensional color Doppler Ultrasonography,found that 2 fetuses were congenital defects children,accounting for 2.29%.Conclusion Eugenic counseling and examination is an inevitable and important measure of pre-pregnancy health care,which can effectively reduce the birth rate of defective children and improve the reproductive health level and population quality of the parturient.