注射用紫杉醇脂质体与胰岛素注射剂在葡萄糖注射剂中的配伍稳定性

Compatibility stability study of the glucose injection with paclitaxel liposome and insulin injection

目的考察在5%葡萄糖注射剂中紫杉醇脂质体与胰岛素配伍的稳定性。方法模拟临床常用药物浓度配制成紫杉醇脂质体与胰岛素的5%葡萄糖注射剂,采用HPLC法考察配伍液中紫杉醇脂质体和胰岛素含量的变化,并测定在室温下放置6 h内配伍液的稳定性变化。结果配伍液在放置6 h内外观和pH值均无明显变化,紫杉醇脂质体、胰岛素的相对含量和包封率保持稳定。结论在室温下放置6 h内,紫杉醇脂质体与胰岛素注射剂在5%的葡萄糖注射剂中配伍稳定。

AIM To investigate the compatibility stability of paclitaxel liposome and insulin in 5% glucose injection. METHODS The 5% glucose injection of paclitaxel liposome and insulin were prepared by simulating the clinical commonly used drug concentrations. The changes of paclitaxel liposome and insulin content in the compatible solution were investigated by HPLC, and the stability of the compatible solution was determined within 6 h at room temperature. RESULTS There were no significant changes of performance,pH value in 6 h and the content of paclitaxel liposome and insulin remained stable. CONCLUSION The compatibility of paclitaxel liposome and insulin in 5% glucose injection is stable in 6 h at room temperature.