临床可应用和潜在的自发性脑出血后血肿扩大预测因素的研究进展

Progress of Hematoma Expansion Predictors after Spontaneous Intracerebral Hemorrhage

自发性脑出血(ICH)是脑卒中的第二大常见病因,发病率较高,近40%的自发性ICH患者出现血肿扩大,且血肿扩大与不良预后和病死率密切相关。因此,对ICH后血肿扩大的早期预测和早期处置极具重要性。文中总结了近几年公认的ICH后预测血肿扩大的可能因子(主要包括影像学特征以及9分临床预测量表和BRAIN 24分临床预测量表),同时对潜在的预测因子(如血糖、C反应蛋白、白细胞介素6等)的研究进展进行综述,以期为临床ICH患者血肿扩大的早期干预提供帮助。

Spontaneous intracerebral hemorrhage( ICH) is the second most common cause of stroke,and its incidence is high,and nearly 40% of patients will develop hematoma expansion,which is closely related to poor prognosis and mortality. Therefore,early prediction and early management of hematoma enlargement are very important. This review summarized the widely recognized hematoma expansion predictors in recent years,mainly including imaging characteristics and two recently proposed rating scales.Potential predictors,such as blood glucose and inflammatory indexes,were introduced in order to provide help for the early intervention of clinical hematoma expansion.