神经源性炎症在复杂性区域疼痛综合征发病中的作用机制研究进展

Research Progress of Neurogenic Inflammation and Its Mechanism in Complex Regional Pain Syndrome

复杂性区域疼痛综合征(CRPS)是一组以疼痛为主要表现的临床综合征,其发病机制尚不明确。神经源性炎症可能是CRPS发病中最先触发的机制,经多系统相互作用产生级联反应,贯穿于CRPS的整个发病过程。文中就近年来神经源性炎症在CRPS发病中的作用机制研究进展做一综述,针对神经源性作用机制选择治疗靶点可能是CRPS治疗的新方向。

Aim The research progress of neurogenic inflammation in complex regional pain syndrome( CRPS) were reviewed,including the mechanism of neurogenic inflammation in the development of CRPS,and exploring whether it can be a new therapeutic target. The role of neurogenic inflammation in the pathogenesis of CRPS,the relationship between neurogenic inflammation and other mechanisms,and the current treatment of neurogenic inflammation were reviewed. Neurogenic inflammation may be the first trigger mechanism in the pathogenesis of CRPS,which runs through the whole pathogenesis of CRPS and is correlated with other mechanisms. Investigation of the role of neurogenic inflammation in the mechanisms might contribute to choosing therapeutic targets.