绒毛膜羊膜炎与早产儿肺部疾病研究进展

Study progress of chorioamnionitis and lung disease in preterm infants

早产是威胁母婴安全的全球关注性问题,在可能导致早产的诸多因素中,绒毛膜羊膜炎(CAM)是最常见的原因。CAM可在胎儿体内产生多种炎性因子,影响胎儿肺脏成熟、引起胎儿肺脏结构重塑,影响肺血管的收缩功能,从而影响早产儿出生后的肺部疾病患病率,甚至对早产儿远期肺功能产生一定的影响,是围生医学关注的重要问题之一。

Preterm birth is a major cause of perinatal mortality and long-term morbidity, chorioamnionitis (CAM) is a common cause of preterm birth and characterized by inflammation.CAM produces variety of inflammatory factors in fetal, results in structural and functional impairment, and affects the contractile function of pulmonary blood vessels, so, CAM can have impact on the morbidity of lung disease in premature, and it may even affect the long-term pulmonary function.