Tavarborole治疗甲真菌病的疗效和安全性

Efficacy and Safety of Tavaborole in the Treatment of Onychomycosis

Tavarborole是一种氧硼戊环类抗真菌药,特异性地抑制亮氨酰转移核糖核酸合成酶抑制真菌蛋白的合成,用于治疗甲真菌病。现对其药效学、药代动力学、临床疗效和安全性等内容进行综述。

Tavaborole is an oxaborole antifungal drug.The medication binds at the enzyme editing site of cytoplasmic leucyl-tRNA synthetase and prevents fun gal protein synthase.In this article,the pharmacodynamics,pharmacokinetics,clinical efficacy,and safety profile of tavaborole has been reviewed.