急性胰腺炎营养支持治疗的最新进展

Recent advances on nutrition in treatment of acute pancreatitis

急性胰腺炎(AP)是一种常见的腹部急性炎症疾病,AP的临床表现多样,轻至可以自限的局部炎症,重至多器官功能衰竭甚至死亡。目前AP治疗手段主要包括液体复苏、生长抑素等非手术治疗和微创、开放性的手术清创治疗。无论哪种治疗方案,营养支持治疗都是其中必不可少的环节。根据AP发病的病理生理学特点,众多学者强调有策略地营养支持治疗是限制局部炎症、预防和控制AP相关并发症的关键。本文将根据AP在营养支持方面的最新进展,包括临床治疗中的肠内与肠外营养策略以及谷氨酰胺、ω-3脂肪酸、维生素和益生菌等营养补充剂方面的最新研究作一综述。

Acute pancreatitis (AP) is a common abdominal acute inflammatory disorder. Clinical manifestations of AP vary from self-limiting local inflammation to multiple organ failure causing significant mortality. At present, AP treatment methods mainly include non-surgical treatment such as fluid resuscitation and somatostatin, and minimally invasive or open surgical debridement treatment. Either treatment programs, nutritional support treatment is an essential part of them. According to the pathophysiological characteristics of AP onset, many scholars have emphasized that strategic nutritional support therapy is the key to limiting local inflammation, preventing and controlling AP-related complications. This article will provide an overview of the latest advances in nutritional support treatment of AP, including enteral and parenteral nutrition strategies in clinical treatment, and nutritional supplements such as glutamine, omega-3 fatty acids, vitamins and probiotics.