胰岛素强化治疗临床缓解相关预测因素的研究进展

Advances in predictors of clinical remission in intensive insulin therapy

对于2型糖尿病患者,早期启动胰岛素强化治疗能快速纠正高血糖状态,改善高糖毒性,减少胰岛素抵抗,保护甚至逆转部分残存的β细胞功能,防止或延缓慢性并发症的发生。因此,该治疗方法在临床应用中越来越广泛。而对于使用胰岛素强化治疗的患者,临床上若能通过疗效影响因素(特别是治疗前的预测指标)及早识别易复发患者,对其及时采取干预措施,对于提高糖尿病治疗率和血糖控制达标率具有重要的意义。

For patients with type 2 diabetes, early intensive insulin therapy can quickly correct hyperglycemia, improve high glucose toxicity, reduce insulin resistance, protect and even reverse partial residual β-cell function and prevent or delay the occurrence of chronic complications. Therefore, this method is more and more widely used in clinical practice. For the patients receiving intensive insulin therapy, it is of great significance to identify the patients who are prone to recurrence as early as possible through the influencing factors (especially the predictive indicators before treatment) and take timely intervention measures to improve the treatment rate of diabetes mellitus and the rate of glycemic control.