度洛西汀联合小剂量奥氮平对83例抑郁症伴自杀倾向患者预后的影响分析

Effects of Duloxetine Combined with Low-dose Olanzapine on Prognosis of 83 Patients with Depression and Suicidal Tendency

目的本文旨在观察度洛西汀联合小剂量奥氮平对抑郁症伴自杀倾向患者预后的影响。方法将83例精神分裂症患者随机分为观察组41例和对照组42例。对照组单用度洛西汀治疗;观察组在对照组基础上加用小剂量奥氮平治疗,疗程均为12周。采用汉密尔顿抑郁量表评分(HAMD)评分评估患者抑郁程度,采用自杀意念自评量表评分(SSIOS)评估患者自杀意念发生情况。结果两组治疗8、12周HAMD评分均较治疗前下降,且观察组下降显著,观察组治疗8周、12周自杀意念发生率分别为60.98%、41.46%显著低于对照组的80.95%、64.29%,两组治疗8、12周SSIOS评分均较治疗前下降,且观察组下降显著,差异均有统计学意义(P<0.05)。结论度洛西汀联合小剂量奥氮平治疗有效改善抑郁症伴自杀倾向患者抑郁症状,明显降低自杀意念发生率。

Objective To investigate the effects of duloxetine combined with low-dose olanzapine on prognosis of patients with depression and suicidal tendency.Methods 83 patients with schizophrenia were randomly divided into observation group(41 cases)and control group(42 cases).The control group was treated with duloxetine.The observation group was treated with low-dose olanzapine on the basis of the control group.The course of treatment was 12 weeks.The Hamilton Depression Scale(HAMD)was performed to assess depression degree of patients.The self-rating idea of suicide scale(SSIOS)was performed to assess the occurrence of suicidal ideation.Results HAMD scores of the two groups at 8 and 12 weeks after treatment were decreased compared with those before treatment.And the decrease in the observation group was significant.The occurrence rates of suicidal ideation in the observation group at 8 weeks and 12 weeks after treatment were 60.98%and 41.46%,respectively.Which were significantly lower than those in the control group(80.95%,64.29%).SSIOS scores of the two groups at 8 and 12 weeks after treatment were decreased compared with those before treatment.And the decrease in the observation group was significant(P<0.05).Conclusion Duloxetine combined with low-dose olanzapine is effective in improving depressive symptoms in patients with depression and suicidal tendency,and can significantly reduce the incidence of suicidal ideation.