猪等孢球虫研究进展

Advance in Isospora suis

猪等孢球虫是一种能引起仔猪球虫病的专性寄生性原虫,可引起仔猪严重腹泻甚至死亡,其发病率可高达50%~75%,病死率高达75%,呈世界性流行,严重危害养猪业发展。目前对仔猪球虫病的防控主要以药物预防为主,随着耐药虫株的不断产生及公众对药物残留的高度关注,使得这一防控手段面临巨大挑战,新型抗猪球虫药物、疫苗及其他防控手段亟待研究开发。论文对猪等孢球虫的生活史、基因组学、免疫学及其与其他微生物的互作关系等方面进行综述,以期为仔猪球虫病的综合防控提供参考。

Piglet coccidiosis is a parasitic protozoan disease caused by Isospora(Cystoisospora)suis,which can cause severe diarrhea and even death in piglets,the morbidity can be as high as 50%-75%,and the mortality is as high as 75%,it leads to considerable economic losses to the swine industry worldwide.In the present,the control of piglet coccidiosis is accomplished by synthetic chemical drug with toltrazuril which is highly effective.However,the emerging problems of anticoccidial resistance and drug residue are of concern regarding piglet coccidiosis,and it is an urgent need to develop new and effective drugs,vaccines or other alternative intervention strategies.This article reviewed the life cycle,genomics,immunity and interactions with other microorganisms in I.suis,in order to provide guidance for the prevention and control of coccidiosis in piglets.