四种类型酒精性肝病对肝脏相关血液指标的影响

Effects of four types of alcoholic liver diseases on hepatic associated blood indicators

探讨四种类型酒精性肝病(ALD)对肝脏相关血液指标的影响。收集住院酒精性肝病137例患者,分为轻症酒精性肝病(MALD)31例,酒精性脂肪肝(AFL)26例,酒精性肝炎(AH)27例,酒精性肝硬化(AC)53例,并选择同期住院的非酒精性肝病患者37例为对照组,分析相关血液指标与酒精性肝病分型之间的关系。所有四种类型酒精性肝病患者的血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(AKP)、γ-谷氨酰转肽酶(γ-GT)均高于对照组;酒精性肝硬化组年龄、谷草转氨酶/谷丙转氨酶(AST/ALT)、凝血酶原时间(PT)、国际标准化比值(INR)大于其他三组和对照组,但血清总蛋白质(TP)、清蛋白(ALB)、白球比(A/G)、总胆固醇(TC)、甘油三酯(TG)、凝血酶原活动度(PTA)、红细胞(RBC)、血红蛋白(HGB)、血细胞压积(HCT)低于其他三组和对照组(P<0.05)。所有酒精性肝病均可造成肝脏酶谱的升高。当病情发展至肝硬化期时,可引起血清蛋白质、血脂及血细胞及凝血指标的改变。

To investigate the effects of four types of alcoholic liver diseases on hepatic associated blood indicators.137 cases of inpatients with alcoholic liver diseases were collected,including 31 cases of inpatients with mild alcoholic liver disease,26 cases of inpatients with alcoholic fatty liver,27 cases of inpatients with alcoholic hepatitis,53 cases of inpatients with alcoholic cirrhosis,and 37 cases of inpatients with non-alcoholic liver disease in the same period were selected as the control group.This study aimed to analyze the relationship between the relevant blood indicators and the above four types of alcoholic liver diseases.The serum of alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,γ-Glutamine transpeptidase of patients with four types of alcoholic liver diseases were higher than the control group,the age,Ratio of aspartate aminotransferase to alanine aminotransferase,prothrombin time and International Standardized Ratio of patients in the group of alcoholic cirrhosis were higher than the other three groups of ALD and the control group,but total protein,albumin,Ratio of albumin to globulin,total cholesterol,triglyceride,prothrombin time,Red blood cell,hemoglobin,Hematocrit in the group of alcoholic cirrhosis were lower than the other three groups of ALD and the control group,the differences were statistically significant(P<0.05).All kinds of alcoholic liver diseases could result in elevated hepatic enzymogram.When the disease developed into liver cirrhosis,it may cause changes of serum proteins,blood lipids,blood cells and coagulation indicator.