急性脑梗死患者血浆Hcy、血管内皮功能和血流动力学的改变及意义

Changes and significance of plasma Hcy,endothelial function and hemodynamics in patients with acute cerebral infarction

探讨血浆同型半胱氨酸(Hcy)、血管内皮功能和血流动力学的改变在急性脑梗死患者的作用及检测意义。选取本院收治的120例急性脑梗死患者为观察组,健康体检者40例为对照组。收集患者血液并检测Hcy、血管内皮功能和血流动力学改变。观察组患者随着患者脑梗死面积的加大,Hcy、MDA、NO、ET含量显著上升,SOD含量显著下降(P<0.05);PWV-β、压力-应变弹性指数(Ep)、僵硬度指数(β)和AI显著上升,AC显著下降(P<0.05);CBF、CBV和MTT显著下降,ICP显著上升(P<0.05)。急性脑梗死患者体内存在高同型半胱氨酸血症和血管内皮功能障碍。随着血浆Hcy水平升高和血管内皮功能障碍的加重,患者神经功能缺损程度越严重。

To investigate the expression and detection of plasma Hcy,vascular endothelial function and hemodynamics in the blood of patients with acute cerebral infarction.120 patients with acute cerebral infarction admitted to our hospital were observed in the observation group and 40 healthy subjects.Patient blood was collected and tested for Hcy,endothelial function,and hemodynamic changes.In the observation group,the levels of Hcy,MDA,NO and ET increased significantly with the increase of cerebral infarct size,and the SOD content decreased significantly(P<0.05).PWV-β,Ep,βand AI increased significantly,and AC decreased significantly(P<0.05);CBF,CBV and MTT decreased significantly,and ICP increased significantly(P<0.05).Hyperhomocysteinemia and endothelial dysfunction are present in patients with acute cerebral infarction.As plasma Hcy levels increase and vascular endothelial dysfunction worsens,the degree of neurological deficits in patients becomes more severe.