白介素21与自身免疫性甲状腺疾病的相关性分析

Correlation Analysis between Interleukin-21 and Autoimmune Thyroid Disease

目的:本研究通过检测Graves病(GD)及桥本氏甲状腺疾病(HT)患者血清IL-21表达水平,探讨IL-21与自身免疫性甲状腺疾病(AITD)、甲状腺功能及其他生化指标之间的相关性。方法:研究组分别为GD组95例(GD-未治疗组54人,GD-治疗组41人),HT组94例(甲功减退HT组44人,甲功正常HT组50人),健康对照组76例,分别检测三组患者血清IL-21水平、甲状腺功能及其他生化指标,使用Epidata3.1软件建立数据库以完成所有数据输入,并使用SPSS 20.0软件进行统计分析。结果:GD组血清IL-21水平(224.09±114.25)pg/mL显著高于对照组(145.86±33.34)pg/mL(P<0.05),HT组血清IL-21水平(212.68±124.25)pg/mL显著高于对照组(145.86±33.34)pg/mL(P<0.05);GD-未治疗组血清IL-21水平(258.49±146.67)pg/mL显著高于GD治疗组(147.46±9.02)pg/mL(P<0.05);HT-甲功减退组(228.76±91.2)pg/mL与HT甲功正常组(201.07±77.98)pg/mL血清IL-21水平差异无统计学意义(P>0.05);GD组血清IL-21水平与FT3、FT4、TPOAb、TGAb呈正相关(r=0.109,r=0.137,r=0.348,r=0.321),差异有统计学意义(P<0.05),与TSH呈负相关(r=-0.034,P>0.05),差异无统计学意义;HT组血清IL-21与甲状腺相关指标均无明显相关性。结论:GD、HT组血清IL-21水平显著升高,GD组血清IL-21与FT3、FT4、TPOAB、TGAB存在相关性,HT组血清IL-21与甲状腺功能无明显相关,推测IL-21可能参与了AITD的发病机制。GD未治疗组血清IL-21水平显著高于GD治疗组,HT甲功减退组、HT甲功正常组血清IL-21水平无明显差异,血清IL-21与GD疾病活动密切相关。

Objective: To investigate the expression of serum IL-21 in patients with Graves disease(GD) and Hashimoto’s thyroid disease(GD),and to explore IL-21 and autoimmune thyroid disease(AITD) and thyroid function and other biochemistry. correlation between indicators.Methods:The study group consisted of 95 patients in the GD group(54 in the GD-untreated group,41 in the GD-treated group),94 in the HT group(44 in the HT group,50 in the normal HT group),and a healthy control.76 patients in the group were tested for serum IL-21 levels and thyroid function and other biochemical indicators in three groups.The database was established using Epidata3.1 software to complete all data input,and statistical analysis was performed using SPSS 25.0 software.The results were analyzed by analysis of variance and correlation analysis.Results:The serum IL-21 level(224.09±114.25) pg/mL in the GD group was significantly higher than that in the control group(145.86±33.34) pg/mL(P<0.05),and the serum IL-21 level in the HT group(212.68±124.25) pg/mL was significant.Higher than the control group(145.86±33.34) pg/mL(P<0.05).Serum IL-21 levels in the GD-untreated group(258.49±146.67) pg/mL were significantly higher than those in the GD-treated group(147.46±9.02) pg/mL(P<0.05).There was no significant difference in serum IL-21 levels between the HT-hypothyroidism group(228.76±91.2) pg/mL and the HT-methyl group(201.07±77.98) pg/mL(P>0.05).Serum IL-21 levels in GD group were positively correlated with FT3,FT4,TPOAb and TGAb(r=0.109,r=0.137,r=0.348,r=0.321),The difference was statistically significant(P<0.05).There was a negative correlation with TSH(r=-0.034,P >0.05),and the difference was not statistically significant.There was no significant correlation between serum IL-21 and thyroid related indexes in HT group. Conclusion:The levels of serum IL-21 in GD and HT groups were significantly increased.There was a correlation between GD serum Il-21 and FT3,FT4,TPOAB and TGAB.There was no significant correlation between serum IL-21 and thyroid function in HT patients.It is speculated that IL-21 may be involved.The pathogenesis of AITD.Serum IL-21 levels in the GD untreated group were significantly higher than those in the GD group,and there was no significant difference in the levels of HT hypothyroidism and HT thyroid function.Serum IL-21 was closely related to GD disease activity.