1型糖尿病住院患者血尿酸与糖尿病肾脏疾病的关系

The Relationship Between Serum Uric Acid Level and Nephropathy in Inpatients With Type 1 Diabetic Mellitus

目的评估血尿酸预测1型糖尿病患者糖尿病肾脏疾病发生的价值。方法采用横断面回顾性研究方法,调阅186例1型糖尿病患者资料,分为:正常蛋白尿组(n=117)、微量蛋白尿组(n=47)、大量蛋白尿组(n=22)。结果①大量蛋白尿组较正常蛋白尿组血尿酸明显升高,差异有统计学意义(P<0.05),其余组间比较差异无统计学意义;②血尿酸与体重指数、收缩压、血肌酐、尿素氮、甘油三酯呈正相关(P<0.05)。③logistic回归分析结果显示糖化血红蛋白A1C((R值1.372,95%CI1.111~1.695)和血尿酸(R值1.006,95%CI1.000~1.011)是影响糖尿病肾脏疾病发生的独立危险因素。结论血尿酸升高是1型糖尿病患者发生糖尿病肾脏疾病的独立危险因素。

Objective To analyze the relationship between serum uric acid level and urinary albumin/urinary creatinine(UACR),and to evaluate the serum uric acid level in predicting the occurrence of diabetic kidney disease(DKD)in patients with type 1 diabetic mellitus.Methods Based on retrospectively cross-sectional study method,186 cases of type 1 diabetic mellitus were enrolled who were treated in the hospital from August 2015 to December 2017.The patients were divided into three groups according to UACR:non-diabetic nephropathy group(n=117),micro-albuminuria group(n=47),and macro-albuminuria group(n=22).Results The serum uric acid level in macro-albuminuria group was higher than that in non-diabetic nephropathy group(P<0.05).The serum uric acid level had the positive correlation with the gender,body mass index,systolic pressure,serum creatinine,blood urea nitrogen and triglyceride.Logistic regression analysis showed that HbA1c and serum uric acid were independent risk factors of DKD.Conclusions The serum uric acid is the independent risk factor of diabetes kidney disease in patients with type 1 diabetic mellitus.