血清炎性因子联合检测对动脉粥样硬化的诊断价值

Combined Detections of Serum Inflammatory Factors for Diagnosis of Atherosclerosis

目的探讨血清炎性因子联合检测对动脉粥样硬化的诊断价值。方法选取2016年9月~2017年9月本院内科门诊检查并确诊为动脉粥样硬化者155例为观察组,同期选取体检中心健康人群100例为对照组,均行颈动脉超声检测及血清炎性因子检测,对比两组血清IL-6、CRP、sICAM-1、Lp-PLA2、apoB水平,采用ROC曲线评价血清炎性因子联合检测对动脉粥样硬化的诊断价值。结果观察组患者血清IL-6、CRP、Lp-PLA2、sICAM-1、apoB水平较对照组升高,差异有统计学意义(P<0.05);Pearson相关性分析发现,动脉粥样硬化患者血清IL-6、CRP、Lp-PLA2、sICAM-1、apoB水平与IMT呈正相关性,P均<0.05;对于各因子单独检测,CRP单独检测AUC最大,达0.868,且其诊断特异度最高,达91.0%,sICAM-1单独检测的诊断敏感度最高,为91.0%;联合检测显示,五项联合检测的AUC最大,为0.929。结论血清炎性因子水平变化与患者动脉粥样硬化程度有关,CRP是动脉粥样硬化诊断的重要指标,联合检测可进一步提高诊断效能。

Objective To explore the diagnostic value of combined detections of serum inflammatory factors in the patients with atherosclerosis.Methods One hundred and fifty-five cases of atherosclerosis were selected for the observation in the hospital and 100 healthy people,as the control.Serum inflammatory factors were detected and the levels of IL-6,CRP,sICAM-1,Lp-PLA2 and apoB were compared between the two groups.ROC curve was used to evaluate the diagnostic value of combined detections of the inflammatory factors.Results The levels of IL-6,CRP,Lp-PLA2,sICAM-1 and apoB in the observation group were significantly higher than those in the control(P<0.05).Pearson correlation analysis showed that IMT of atherosclerotic patients were positively correlated with the levels of serum IL-6,CRP,Lp-PLA2,sICAM-1 and apoB(P<0.05).For the individual detection of each factor,CRP had the largest AUC(0.868),with the highest specificity(91%),and the highest sensitivity(91%)of sICAM-1 was also noted.Combined detections resulted in the highest AUC(0.929).Conclusion The results of combined detections of serum inflammatory factors are related to the progress of atherosclerosis.CRP is a useful marker for the diagnosis of atherosclerosis.