盐酸氨溴索与阿奇霉素联合治疗对支原体肺炎患儿免疫功能与临床效果的影响

Effect of Ambroxol Hydrochloride combined with Azithromycin on Immune Function and Clinical Effect in Children with Mycoplasma Pneumonia

目的探讨盐酸氨溴索联合阿奇霉素治疗支原体肺炎患儿临床效果及对免疫功能的影响。方法选取我院(2015年1月至2017年1月)收治的90例支原体肺炎患儿,对照组(n=45)给予阿奇霉素治疗,观察组(n=45)在对照组基础上给予盐酸氨溴索治疗,对比两组患儿临床疗效和临床症状消失时间以及治疗前后免疫功能和肺功能。结果两组患儿临床疗效93.33%vs80.00%对比差异明显,具有统计学意义(P<0.05)。两组患儿临床症状消失时间对比差异明显,具有统计学意义(P<0.05)。治疗后两组患儿CD3^+、CD4^+、CD8^+对比差异明显,具有统计学意义(P<0.05)。两组患儿FVC、FEV1、PEF对比差异明显,具有统计学意义(P<0.05)。结论盐酸氨溴索与阿奇霉素联合治疗能显著改善支原体肺炎患儿免疫功能,临床效果满意。

Objective To investigate the clinical effect of ambroxol hydrochloride combined with azithromycin on children with mycoplasma pneumonia and its influence on immune function.Methods Ninety children with mycoplasma pneumonia admitted to our hospital from January 2015 to January 2017 were selected.The control group(n=45)was treated with azithromycin,while the observation group(n=45)was treated with ambroxol hydrochloride on the basis of the control group.The clinical efficacy,disappearance time of clinical symptoms,immune function and pulmonary function before and after treatment were compared between the two groups.Result The clinical curative effect of the two groups was 93.33%vs 80.00%,the difference was significant(P<0.05).There was significant difference in the disappearance time of clinical symptoms between the two groups(P<0.05).After treatment,there were significant differences in CD3^+,CD4^+,CD8^+between the two groups(P<0.05).There were significant differences in FVC,FEV1 and PEF between the two groups(P<0.05).Conclusion Ambroxol hydrochloride combined with azithromycin can significantly improve the immune function of children with Mycoplasma pneumonia,and the clinical effect is satisfactory.