COPD患者WBC、CRP、PCT水平变化及其临床意义

Change of WBC,CRP and PCT levels and their clinical significance in patients with COPD

目的测定血清降钙素原(PCT)、C反应蛋白(CRP)及白细胞计数(WBC)在慢性阻塞性肺疾病(COPD)患者中的水平,探讨其水平变化在COPD急性加重期(AECOPD)中的临床意义。方法选取2014年1月至2016年12月在该院老年病科住院的50例AECOPD患者为试验组,30例经体检显示身体状况良好的健康体检者为对照组。对两组人员血清PCT、CRP及WBC水平进行测定。以入院时COPD患者痰液颜色作为分类依据,把试验组患者分为两组,其中脓痰组20例,非脓痰组30例,并检测PCT、CRP、WBC水平。结果试验组患者血清PCT水平为(2.10±0.48)ng/mL,对照组为(0.24±0.06)ng/mL,差异有统计学意义(P<0.05);试验组患者血清CRP水平为(34.85±6.87)mg/L,而对照组为(5.42±1.18)mg/L,差异有统计学意义(P<0.05);试验组患者WBC水平为(15.48±1.57)×10^9/L,而对照组为(6.21±0.12)×10^9/L,差异有统计学意义(P<0.05)。脓痰组患者血清PCT水平为(2.36±0.88)ng/mL,CRP水平为(38.64±1.32)mg/L,WBC水平为(18.98±2.15)×10^9/L,与非脓痰组比较,差异均有统计学意义(P<0.05)。结论测定患者血清PCT、CRP及WBC水平可以作为判断AECOPD的辅助手段。根据这些指标变化,可以对患者进行有效的针对性治疗。

Objective To determine the levels of calcitonin(PCT),C reactive protein(CRP)and leukocyte(WBC)in the patients with chronic obstructive pulmonary disease(COPD),and to explore the clinical significance of their level change on the acute exacerbation of COPD(AECOPD).Methods Fifty inpatients with AECOPD in the geriatric department of this hospital from January 2014 to December 2016 were selected as the experimental group,and 30 individuals of good health by physical examination served as the control group.Serum PCT,CRP and blood WBC levels were measured in the two groups.The experimental group was re-divided into the two groups according to the sputum color at admission,including 20 cases in the purulent sputum group and 30 cases in the non-purulent sputum group,and the levels of above indexes were detected.Results The serum PCT level in the experimental group was(2.10±0.48)ng/mL,which in the control group was(0.24±0.06)ng/mL,and the difference between the two groups was statistically significant(P<0.05);the serum CRP level in the experimental group was(34.85±6.87)mg/L,while which in the control group was(5.42±1.18)mg/L,and the difference was statistically significant(P<0.05);the blood WBC level in the experimental group was(15.48±1.57)×10^9/L,while which in the control group was(6.21±0.12)×10^9/L,and the difference was statistically significant(P<0.05);the serum PCT level in the purulent sputum group was(2.36±0.88)ng/mL,serum CRP level was(38.64±1.32)mg/L and the blood WBC level was(18.98±2.15)×10^9/L,showing statistical difference compared with the non-purulent sputum group(P<0.05).Conclusion The determination of serum PCT,CRP and blood WBC levels can serve the auxiliary means for judging AECOPD.According to the change of these indicators,the effective targeted treatment on the patients can be performed.