奥沙利铂联合卡培他滨对进展期胃癌化疗的效果评价

Efficacy of Oxaliplatin Combined with Capecitabine in the Treatment of Advanced Gastric Cancer

目的:评价采用奥沙利铂联合卡培他滨对进展期胃癌进行化疗的临床效果。方法:于我院选取64例进展期胃癌患者进行研究,依据随机分配原则将其分为研究组(32例)与参照组(32例)。研究组患者采用奥沙利铂联合卡培他滨进行化疗治疗,参照组患者采用表柔比星、顺铂和氟尿嘧啶(ECF方案)进行化疗治疗,对比两组方案的治疗效果、患者1年生存率以及不良反应发生率。结果:研究组患者治疗的总有效率(68.75%)高于参照组(43.75%);研究组患者的骨髓抑制和肠胃道反应发生率显著低于参照组;研究组患者的1年生存率(84.38%)明显高于参照组(62.50%),差异具统计学意义(P<0.05)。结论:采用奥沙利铂联合卡培他滨对进展期胃癌进行化疗治疗的效果显著,可有效控制病情的发展,延长胃癌患者生存时间,且药物毒副作用较少,可减少患者的不适感,安全性较高,值得推广。

Objective:To evaluate the clinical effect of oxaliplatin combined with capecitabine in the treatment of advanced gastric cancer.Methods:64 patients with advanced gastric cancer were randomly divided into study group(32 cases)and control group(32 cases).Patients in the study group were treated with oxaliplatin combined with capecitabine,and those in the control group were treated with epirubicin,cisplatin and fluorouracil(ECF regimen).The 1-year survival rate and the incidence of adverse reactions were observed.Results:The total effective rate of treatment in study group was 68.75%.The incidence of bone marrow suppression and gastrointestinal tract reaction in the study group was significantly lower than that in the control group(43.75%).The 1-year survival rate in the study group(84.38%)was significantly higher than that in the control group(62.50%)(P<0.05).Conclusion:Oxaliplatin combined with capecitabine is effective in the treatment of advanced gastric cancer.It can effectively control the development of gastric cancer,prolong the survival time of gastric cancer patients,and reduce the discomfort of patients.It is worth popularizing because of its high safety.