他汀类药物对慢性心力衰竭的临床治疗效果和安全性评价

Evaluation of the Effect and Safety of Statins on the Clinical Treatment of Chronic Heart Failure

目的:分析研究在慢性心力衰竭病患的治疗中应用他汀类药物的临床治疗效果及安全性。方法:选取2017年1月1日至2018年1月1日128例在我院接受慢性心力衰竭治疗的病患,随机将病患分为两组,其中一组病患给予标准治疗设为标准组,另一组病患在标准组的基础上给予他汀类药物进行治疗设为他汀组,每组各64例病患,对两组病患的总体治疗效果及不良反应情况进行对比。结果:两组病患经治疗后,他汀组病患的总体治疗有效率为87.5%,标准组总体治疗有效率为71.9%,他汀组病患的总体治疗有效率明显高于标准组病患(P<0.05);且他汀组病患的左心室射血分数、6min步行试验、心功能分级情况明显优于标准组(P<0.05);两组病患不良反应情况对比无明显差异(P>0.05)。结论:在慢性心力衰竭病患的治疗中应用他汀类药物,可提高临床治疗效果,且未见不良反应增加,安全性高,值得在临床上大力的推广实行。

Objective:To analyze the efficacy and safety of statins in the treatment of patients with chronic heart failure.Methods:From January 1,2017 to January 1,2018,128 patients with chronic heart failure in our hospital were randomly divided into two groups,with 64 in each:one of which received standard treatment as the standard group,and the other group of patients were treated with statins on the basis of the standard group.The overall therapeutic effects and adverse reactions were compared between the two groups.Results:After the two groups of patients were treated,the total number of patients in the statins group was significantly higher than that in the control group.The total effective rate in the statins group was 87.5%,and that in the standard group was 71.9%.The total effective rate of patients in statins group was significantly higher than that in standard group(P<0.05).The left ventricular ejection fraction(LVEF),6 min walking test and cardiac function grading in the statins group were significantly better than those in the standard group(P<0.05).And there was no significant difference in the adverse reactions between the two groups(P>0.05).Conclusion:The application of statins in the treatment of chronic heart failure can improve the effect of clinical treatment,and there is no increase in adverse reactions witn high safety.Therefore,it is worth popularizing and implementing in clinical practice.