血脂康胶囊与阿托伐他汀钙片治疗老年腔隙性脑梗死伴高脂血症、高血压前期患者临床疗效的比较

Comparison of Clinical Efficacy of Xuezhikang Capsule and Atto Vastatin Calcium Tablets in the Treatment of Senile Lacunar Cerebral Infarction with Hyperlipidemia and Prehypertension

目的:比较血脂康胶囊和阿托伐他汀钙片在老年腔隙性脑梗死伴高脂血症、高血压前期患者中的治疗效果。方法:将2016年7月至2018年5月在我院接受治疗的老年腔隙性脑梗死伴高脂血症、高血压前期患者84例随机分为研究组和对照组,每组42例。研究组采用血脂康胶囊进行治疗,对照组采用阿托伐他汀钙片进行治疗。比较两组患者治疗前后的平均动脉压(MAP)、谷氨酰转肽酶(GGT)、肌酸激酶(CK)、超敏C-反应蛋白(hs-CRP)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)的变化情况以及收缩压(SBP)、舒张压(DBP)变化情况。结果:治疗前,两组患者的MAP、GGT、CK、hs-CRP水平差异无统计学意义(P>0.05);治疗后,研究组的MAP、GGT、CK、hs-CRP水平低于对照组,且差异具有统计学意义(P<0.05)。治疗前、后,研究组的TG、TC、HDL-C、LDL-C水平与对照组相比差异无统计学意义(P>0.05)。治疗前,两组患者的SBP、DBP水平无统计学意义(P>0.05);治疗后,研究组的SBP、DBP水平均但低于对照组,且差异具有统计学意义(P<0.05)。结论:在老年腔隙性脑梗死伴高脂血症、高血压前期患者的治疗中,血脂康胶囊和阿托伐他汀钙片的降脂作用不相上下,血脂康胶囊可对心血管疾病进行更明显的改善,同时能发挥更显著的降压效果。

Objective:To compare the therapeutic effects of Xuezhikang capsule and Atto vastatin calcium tablets in senile patients with lacunar cerebral infarction combined hyperlipidemia and prehypertension.Methods:From July 2016 to May 2018,84 cases of senile lacunar cerebral infarction with hyperlipidemia were randomly divided into study group and control group with 42 cases in each group.The study group was treated with Xuezhikang capsule and the control group with Atto vastatin calcium tablets.The mean arterial pressure(MAP),glutamyl transpeptidase(GGT),creatine kinase(CK),hypersensitive C-reactive protein(hs-CRP),triglyceride(TG),total cholesterol,(TC),high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C)and systolic pressure(SBP),diastolic blood pressure(DBP)were compared between the two groups.Results:There was no significant difference in MAP,GGT,CK,hs-CRP level between the two groups before treatment(P>0.05).After treatment,the level of MAP,GGT,CK,hs-CRP in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in TG,TC,HDL-C,LDL-C level between the two groups before or after the treatment(P>0.05).There was no significant difference in SBP,DBP level between the two groups before treatment(P>0.05),but the level of SBP,DBP in the study group was lower than that in the control group after treatment,and the difference was statistically significant(P<0.05).Conclusion:Xuezhikang capsule and Atto vastatin calcium tablet have the same effect on reducing lipid in senile patients with lacunar cerebral infarction and hyperlipidemia.Xuezhikang capsule can improve cardiovascular disease more obviously.and has a better significant depressurization effect.