附子理中汤治疗腹泻型肠易激综合征的疗效观察

Clinical efficacy of diarrhea predominant irritable bowel syndrome treated with Fuzi Lizhong Decoction

目的探究附子理中汤对腹泻型肠易激综合征的临床疗效及对血清中炎症因子的影响。方法选择2016年5月至2018年4月期间接收的120例腹泻型肠易激综合患者为研究对象,按随机数字表法将研究对象随机分为对照组和治疗组,每组60例。对照组给予匹维溴铵,治疗组给予附子理中汤。对比两组治疗后的总有效率,对比两组治疗前后的IBS生活质量评分、SF-36生活质量评分以及血清中C反应蛋白(C-reactive protein,CRP)、肿瘤坏死因子-α(Tumor Necrosis Factor-α,TNF-α)和白细胞介素-6(Interleukin-6,IL-6)水平。结果治疗组总有效率优于对照组(P <0. 05);两组患者治疗后的IBS生活质量评分和SF-36生活质量评分均优于治疗前,治疗组治疗后IBS生活质量评分和SF-36生活质量评分优于对照组(P <0. 05);两组治疗后血清中CRP、TNF-α和IL-6水平均低于治疗前,治疗后治疗组血清中CRP、TNF-α和IL-6水平均低于对照组(P <0. 05)。结论附子理中汤治疗腹泻型肠易激综合征的临床疗效显著,改善患者的炎症反应效果更理想。

Objective To study the clinical efficacy of diarrhea predominant irritable bowel syndrome treated with Fuzi Lizhong Decoction and its effect on serum inflammatory factors.Methods From May 2016 to April 2018,120 patients with diarrhea-predominant irritable bowel syndrome were randomly divided into control group and treatment group with 60 cases in each group.The control group was treated with P-bromide,and the treatment group was given with Fuzi Lizhong Decoction.The total effective rate of the two groups after treatment was compared.The IBS quality of life score,SF-36 quality of life score,and serum levels of C-reactive protein(CRP),tumor necrosis factor-alpha(TNF-alpha)and interleukin-6(IL-6)were compared between the two groups before and after treatment.Results The total effective rate of treatment group was significantly higher than that of the control group(P<0.05).The scores of IBS quality of life and SF-36 quality of life after treatment in both groups were significantly higher than those before treatment.The scores of IBS quality of life and SF-36 quality of life in the treatment group were significantly higher than those in the control group after treatment(P<0.05).The serum levels of CRP,TNF-a and IL-6 in both groups were significantly lower than those before treatment.The serum levels of CRP,TNF-a and IL-6 in the treatment group were significantly lower than those in the control group after treatment(P<0.05).Conclusions Fuzi Lizhong Decoction have significant clinical effects on diarrhea-predominant irritable bowel syndrome,and the effect of improving inflammation is better.