中药益气活血方治疗急性心肌梗死并急诊PCI术患者的临床研究

Clinical Study on Benefiting Qi for Activating Blood Circulation Prescription in the Treatment of Acute Myocardial Infarction with Emergency PCI Operation

目的研究中药益气活血方治疗急性ST段抬高型心肌梗死并行急诊经皮冠状动脉支架置入术(急诊PCI术)患者的临床疗效。方法选择我院收治的急性ST段抬高型心肌梗死并行急诊PCI术的患者106例;应用随机数字表法分为对照组和研究组,每组53例,对照组在行急诊PCI术后给予常规药物治疗,研究组在行急诊PCI术后常规治疗的基础上再给予口服中药益气活血方。比较2组患者入院即刻和急诊PCI术后的心功能(左室射血分数)、血清心肌坏死标志物[肌酸激酶同工酶(CK-MB)、心肌肌钙蛋白T(cTnT)]水平。结果 2组入院即刻上述指标差异无统计学意义(P> 0. 05); 2组急诊冠状动脉支架置入术后的心功能、心肌坏死标志物水平差异均有统计学意义(均P <0. 05),研究组优于对照组。结论中药益气活血方能有效改善急性ST段抬高型心肌梗死并行急诊PCI术患者的心功能和血清心肌坏死标志物水平。

Objective To study the effect of benefiting qi for activating blood circulation prescription on oxidative stress in patients with emergency percutaneous coronary stent implantation.Methods Patients with emergency coronary stenting were randomly divided into treatment group and control group by method of random number table.The control group received conventional drug treatment.The treatment group was given benefiting qi for activating blood circulation prescription.The Superoxide Dismutase,Glutathione peroxidase and Malondialdehyde were measured in serum at the time of admission to the hospital and after coronary stent implantation.Results The serum Superoxide Dismutase and Glutathione peroxidase increased significantly and Malondialdehyde decreased significantly after treatment(P<0.05).Conclusion The benefiting qi for activating blood circulation prescription can effectively improve the cardiac function and the level of serum myocardial necrosis markers in patients with acute ST segment elevation myocardial infarction and emergency PCI.