摘要
砷是一种广泛分布于自然环境的污染物,肝脏是砷毒性的主要靶器官之一,砷通过影响肝细胞凋亡的失衡从而造成肝脏损伤并引起肝脏疾病,然而其具体影响机制并不是十分明确。文中就近年来国内外砷导致肝细胞凋亡的通路和影响因素研究进行综述,为未来肝损伤机制的研究和临床防治提供一定参考。
Arsenic is a pollutant widely distributed in the natural environment. The liver is one of the main target organs of arsenic toxicity. Arsenic causes liver damage and liver disease by affecting the imbalance of hepatocyte apoptosis. However, its specific mechanism is not very clear. In this paper, the research on pathways and influencing factors of arsenic-induced hepatocyte apoptosis in recent years is reviewed, which might provide a reference for the mechanism study and clinical prevention of liver injury in the future.
作者
刘振宇
王克维
郦芒
孙殿军
Liu Zhenyu;Wang Kewei;Li Mang;Sun Dianjun(Institute for Endemic Fluorosis Control, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China;Institute of Cell Biotechnology, China and Russia Medical Research Center, Harbin Medical University, Harbin 150081, China;Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China)
出处
《中华地方病学杂志》
CAS
CSCD
北大核心
2019年第5期418-421,共4页
Chinese Journal of Endemiology
关键词
砷中毒
肝细胞
细胞凋亡
Arsenic poisoning
Hepatocytes
Apoptosis
