化积止痛汤治疗子宫腺肌病痛经的临床观察

Clinical observation of Huaji Zhitong decoction in the treatment of adenomyosis

目的:观察化积止痛汤治疗子宫腺肌病的疗效和安全性。方法:根据纳入标准,随机将符合标准的子宫腺肌病70例平均分为化积止痛汤治疗组和止痛化癥胶囊对照组。观察比较两组患者治疗前及治疗1疗程后痛经积分、月经量评分、子宫体积、CA125水平以及不良反应情况。结果:治疗后3个月,治疗组痛经VAS评分明显低于对照组(P<0.05);治疗组月经量PBAC评分、CA125水平下降显著(P<0.05);两组均未见子宫体积明显缩小。结论:化积止痛汤可以改善子宫腺肌病患者痛经程度、降低月经量及CA125水平,有良好的临床应用价值。

Objective: To observe the efficacy and safety of Huaji Zhitong decoction in the treatment of adenomyosis. Methods: Seventy cases of patients with adenomyosis were randomly divided into a treatment group (oral Huaji Zhitong decoction) and a control group (oral Zhitong Huazheng capsule) based on the inclusion criteria. The dysmenorrhea score, menstrual volume score, uterine volume, CA125 level and adverse reactions were observed before treatment and 1 course after and compared between the two groups. Results: The VAS score of dysmenorrhea in the treatment group was significantly lower than that in the control group at 3 months after treatment (P<0.05). The PBAC score and CA125 level in the treatment group were significantly decreased (P<0.05). The uterine volume was not significantly reduced in both groups. Conclusion: Huaji Zhitong decoction can improve the degree of dysmenorrhea, reduce the menstrual volume and CA125 level in patients with adenomyosis and has good clinical application value.