布拉酵母治疗小儿轮状病毒性胃肠炎的疗效及对病程的影响

Clinical effect of Saccharomyces boulardii in the treatment of pediatric rotavirus gastroenteritis and its influence on the course of disease

目的:探究布拉酵母与双歧杆菌四联活菌对小儿轮状病毒性胃肠炎的临床治疗效果以及病程影响情况。方法:采用数字随机表法将选取的88例小儿轮状病毒性胃肠炎患儿分成对照组和观察组各44例,在两组患儿均给予常规治疗的基础上,对照组给予双歧杆菌四联活菌而观察组给予布拉酵母治疗,比较两组患儿的临床效果以及病程情况。结果:观察组疗效优良率显著高于对照组(95.45%vs86.36%,P<0.05)。治疗后,观察组大便次数、腹泻持续时间、粪便轮状病毒转阴时间、退热时间显著少于对照组(P<0.05)。结论:布拉酵母治疗小儿轮状病毒性胃肠炎可显著改善患儿临床疗效,对于减少腹泻次数及缩短病程有重要临床价值。

Objective: To explore the clinical effect of Saccharomyces boulardii and the combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus in the treatment of pediatric rotavirus gastroenteritis and its influence on the course of disease. Methods: Eighty-eight cases of children with rotavirus gastroenteritis were selected and divided into a control group and an observation group with 44 cases each by a digital random table method. All of the patients were given routine treatment and besides, the control group was treated with the combined Bifidobacterium, Lactobacillus, Enterococcus and Bacillus and the observation group with Saccharomyces boulardii. The clinical effects and the duration of disease course were compared between the two groups. Results: The excellent and good rates of clinical efficacy were significantly higher in the observation groups than the control group (95.45% vs 86.36%, P<0.05). After the treatment, the number of stools, the duration of diarrhea, the fecal rotavirus negative conversion time and the fever abatement time were significantly less in the observation group than the control group (P<0.05). Conclusion: The Saccharomyces boulardii for the treatment of pediatric rotavirus gastroenteritis can significantly improve the clinical effect of patients and has important clinical value in reducing the frequency of diarrhea and shortening the course of disease.