TERT启动子突变与尿路上皮肿瘤的研究进展

Research progress of TERT promoter mutation in urothelial cancer

端粒酶可赋予真核细胞无限增殖的能力,而端粒酶逆转录酶(TERT)是端粒酶活化的重要催化亚单位,其启动子的突变与多种肿瘤包括尿路上皮癌密切相关,提示其是肿瘤形成过程中的始动因素。该文将就近年来TERT启动子突变与尿路上皮肿瘤的发生、相关作用机制及潜在的临床应用价值等方面的研究展开综述。

Telomerase activity imparts eukaryotic cells with unlimited proliferation capacity.Telomerase reverse transcriptase(TERT) is the key catalytic subunit of telomerase activation,the mutation of its promoter is closely related to a variety of tumors,including urothelial cancer(UC),which suggests that TERT is the initiating factor in the process of tumor formation.This article reviews recent researches on the relationship between TERT promoter mutation and the occurrence of urothelial cancer,its related mechanisms of action and potential clinical application,etc.