EB病毒合并支原体肺炎患儿的临床特征及免疫功能

Clinical Characteristics and Immune Function of Children with EB Virus Complicated with Mycoplasmal Pneumonia

目的探讨EB病毒伴有支原体肺炎患儿表现出的免疫功能以及疾病特征。方法方便选择该院2016年8月—2018年6月收治的45例EB病毒伴有支原体肺炎患儿作为实验观察组;同时间段选择45名健康儿童作为实验对照组;对比两组免疫功能以及疾病特征。结果同对照组健康儿童中性粒细胞降低率(4.44%)、谷丙转氨酶异常率(2.22%)、肌酸激酶同工酶异常率(0.00%)、大叶实变率(0.00%)以及尿常规异常率(4.00%)对比,观察组EB病毒伴有支原体肺炎患儿(26.67%)、(37.78%)、(40.00%)、(55.56%)以及(40.00%)均表现出明显提升(χ^2=8.0049,16.5079,20.8929,30.9524,15.1273P<0.05);观察组儿童CD4水平为(28.89±6.05)%,CD8水平为(37.65±4.07)%,CD4/CD8水平为(0.76±0.25),对照组儿童CD4水平为(37.06±7.16)%,CD8水平为(24.46±4.76)%,CD4/CD8水平为(1.55±0.07);同对照组健康儿童免疫功能指标对比,观察组EB病毒伴有支原体肺炎患儿CD4水平以及CD4/CD8水平呈现出明显降低,CD8水平呈现出明显提升(P<0.05)。结论患儿在表现出EB病毒伴有支原体肺炎的现象后,表现出的感染现象较为严重,并发症数量较多,并且会导致患儿呈现出免疫功能紊乱的现象,在临床治疗期间,需要将免疫功能调节力度充分加强,对于患儿健康恢复,明显促进。

Objective To investigate the immune function and disease characteristics of children with Epstein-Barr virus associated with mycoplasmal pneumonia. Methods 45 patients with EB virus associated with mycoplasmal pneumonia admitted to our hospital from August 2016 to June 2018 were convenient selected as experimental observation group. At the same time, 45 healthy children were selected as experimental control group. The immune function and disease characteristics of the two groups were compared. Results The neutrophil reduction rate (4.44%), alanine aminotransferase abnormal rate (2.22%), creatine kinase isoenzyme abnormal rate (0.00%), and large leaf consolidation rate (0.00%) and the abnormal urine abnormal rate (4.00%) in healthy children in the same control group, the observation group EB virus with mycoplasma pneumonia (26.67%),(37.78%),(40.00%),(55.56%) and (40.00%) showed significant improvement (χ^2=8.004 9, 16.597 9, 20.892 9, 30.952 4, 15.127 3,P<0.05);the CD4 level of the observation group was (28.89±6.05)%, the CD8 level was (37.65±4.07)%, and the CD4/CD8 level was (0.76±0.25). The CD4 level of the control group was (37.06±7.16)%, the CD8 level was (24.46±4.76)%, and the CD4/CD8 level was (1.55±0.07). Compared with the immune function indicators of healthy children in the control group, the observation group EB virus CD4 levels and CD4/CD8 levels were significantly lower in children with mycoplasmal pneumonia, and CD8 levels were significantly increased (P<0.05). Conclusion After showing the phenomenon of EB virus with mycoplasmal pneumonia, the children showed more serious infections and more complications, which may lead to immune dysfunction. During clinical treatment, it is needed that the immune function adjustment intensity is fully strengthened, and the recovery of the child's health is obviously promoted.