外源性一氧化氮吸入对新生儿低氧性呼吸衰竭症状及心功能的影响

Effect of Exogenous Nitric Oxide Inhalation on Symptoms and Cardiac Function of Neonatal Hypoxic Respiratory Failure

目的分析新生儿低氧性呼吸衰竭症状临床治疗中,采用外源性一氧化氮吸入治疗方法取得的治疗效果。方法2016年12月—2017年12月,方便选取该院低氧性呼吸衰竭患儿82例,采用常规机械通入氧气治疗的41例纳入对照组,采用外源性一氧化氮吸入治疗的41例纳入观察组,对两组患儿治疗效果。结果治疗后,观察组氧和指数、PaCO2分别为(5.6±1.7)、(31.2±2.5)mmHg低于对照组(8.0±1.5)、(43.6±4.0)mmHg,平均气道压、PaO2、心率、心博指数、左心室射血分数分别为(12.8±1.3)cmH2O、(68.5±3.5)mmHg、(78.8±1.5)次/min、(3.6±0.2)L/(min·m^2)、(79.8±1.4)%高于对照组(9.4±1.5)cmH2O、(52.4±1.6)mmHg、(72.6±1.7)次/min、(3.0±0.4)L/(min·m^2)、(72.5±1.6)%,组间对比差异有统计学意义(t=6.778、16.832、10.968、26.788、17.511、8.591、21.986,P<0.05)。结论采用外源性吸入一氧化氮方法,可取得显著治疗效果,值得推广。

Objective To analyze the therapeutic effect of exogenous nitric oxide inhalation therapy in the clinical treatment of neonatal hypoxic respiratory failure. Methods From December 2016 to December 2017, 82 children with hypoxic respiratory failure were convenient selected and enrolled in the hospital. 41 patients who received conventional mechanical oxygen therapy were included in the control group, and 41 patients who received exogenous nitric oxide inhalation were included in the observation group. The clinical efficacy of the two groups of children were compared. Results After treatment, the observed oxygen and index, PaCO2 were (5.6±1.7),(31.2±2.5) mmHg lower than the control group (8.0 ± 1.5),(43.6 ± 4.0) mmHg, mean airway pressure, PaO2, heart rate, cardiac index, and left ventricular ejection fraction were (12.8±1.3)cmH2O,(68.5±3.5)mmHg,(78.8±1.5)times/min,(3.6±0.2)L/(min·m^2),(79.8±1.4)% higher than the control group (9.4±1.5)cmH2O,(52.4±1.6)mmHg,(72.6±1.7)times/min,(3.0±0.4)L/(min·m^2),(72.5±1.6)%, there was a significant difference between the groups (t=6.778, 16.832, 10.968, 26.788, 17.511, 8.591, 21.986, P<0.05). Conclusion The use of exogenous inhaled nitric oxide can achieve significant therapeutic effects and is worthy of promotion.