临床药学干预对呼吸内科合理使用抗生素的作用

Effect of Clinical Pharmacy Intervention on Rational Use of Antibiotics in Respiratory Medicine

目的通过对呼吸内科患者实施不同的临床干预,观察不同干预方法的临床效果,探究不同临床干预的临床特点。方法2018年1—10月间从来该院诊治的呼吸内科患者中随机抽取55例,采用随机数字法随机分为对照组28例:实施常规抗生素治疗,观察组27例:实施临床药学干预,比较两组的抗生素使用及住院时间情况、不良反应发生率、病原学检测率及三联以上抗生素使用率。结果观察组住院时间为(7.61±1.53)d低于对照组(t=14.241,P<0.05),抗生素疗程为(5.39±1.81)d低于对照组(t=11.641,P<0.05),抗生素费用为(755.82±14.62)元低于对照组(t=12.482,P<0.05);观察组不良反应发生率11.11%低于对照组(χ^2=8.428,P<0.05),病原学检测率为14.81%低于对照组(χ^2=7.982,P<0.05),三联以上抗生素使用率为7.41%低于对照组(χ^2=9.742,P<0.05),差异有统计学意义(P<0.05)。结论临床药学干预可以有效降低呼吸内科的住院时间、抗生素疗程、抗生素费用,减少不良反应、病原学检测及三联以上抗生素使用情况,是一项值得推广的临床干预。

Objective To observe the clinical effects of different intervention methods by different clinical interventions in patients with respiratory medicine, and to explore the clinical characteristics of different clinical interventions. Methods A total of 55 patients with respiratory medicine from January 2018 to October 2018 in our hospital were randomly selected and randomly divided into control group (n=28): routine antibiotic treatment, observation group: 27 cases: clinical pharmacy Interventions were used to compare antibiotic use and length of hospital stay, incidence of adverse events, etiology, and antibiotic use rates above the triple. Results The hospitalization time of the observation group was (7.61±1.53)d lower than that of the control group (t=14.241, P<0.05), the antibiotic course was (5.39±1.81)d lower than the control group (t=11.641, P<0.05), and the antibiotic cost was (755.82±14.62)yuan was lower than the control group (t=12.482, P<0.05);the incidence of adverse reactions in the observation group was 11.11% lower than that in the control group (χ^2=8.428, P<0.05), and the pathogen detection rate was 14.81% lower than the control group (χ^2=7.982, P<0.05), the use rate of triple antibiotics was 7.41% lower than that of the control group (χ^2=9.742, P<0.05),the different was statistically significant(P<0.05). Conclusion Clinical pharmacological intervention can effectively reduce the hospitalization time, antibiotic course, antibiotics of respiratory medicine cost, reducing adverse reactions, pathogen detection and the use of antibiotics above the triple is a clinical intervention worthy of promotion.