喹硫平对女性精神分裂症患者甲状腺功能的影响及相关因素分析

Effect of quetiapine on thyroid function and related factors in female schizophrenic patients

目的探索喹硫平对女性精神分裂症患者甲状腺功能的影响及相关因素。方法选取90例精神分裂症患者,使用喹硫平单药治疗,观察8周,分别于基线时及治疗后第8周末抽血检测甲状腺功能五项指标包括促甲状腺素(TSH)、总三碘甲状腺原氨酸(TT3)、总甲状腺素(TT4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)。结果治疗8周后,TT3、TT4、FT3、FT4均较治疗前下降(P<0.05);FSH较治疗前上升(P<0.05);基线时TT3、TT4、FT3、FT4各项指标均与治疗前后TT3、TT4、FT3、FT4的差值呈负相关(P<0.05);基线时FSH与治疗前后FSH的差值呈负相关(P<0.05)。年龄、喹硫平的剂量均不是甲状腺功能各项指标变化的影响因素。结论喹硫平治疗急性期女性精神分裂症患者的过程中,可能会出现甲状腺功能各项指标的变化,应注意加强监测。

Objective To explore the effect of quetiapine on thyroid function in female schizophrenic patients and related factors.Methods,A total of 90 patients with schizophrenia were selected and treated with quetiapine for 8 weeks. Blood samples were collected at baseline and at the end of the 8 th week after treatment respectively for assessing TSH, TT3,TT4,FT3,FT4.Results,After the 8-week treatment, levels of TT3, TT4, FT3 and FT4 decreased significantly compared with those before treatment( P <0.05);and the level of FSH increased significantly compared with that before treatment( P <0.05). Levels of TT3, TT4, FT3, FT4 and FSH at baseline were negatively correlated with the differences in TT3, TT4, FT3, FT4 and FSH before and after treatment ( P <0.05). Age and dose of quetiapine were not the contributory factors of changes in thyroid function. ConclusionQuetiapine may cause changes in thyroid function indicators during the treatment of acute female schizophrenia, and periodic monitoring should be reinforced.