山东地区青年人群初发Graves病患者抑郁状态分布及危险因素分析

An analysis of distribution and risk factors of depressive state in young patients with incipient Graves Disease (GD) in Shandong province

目的分析山东地区青年人群初发Graves病(GD)患者抑郁状态及危险因素。方法收集1158名青年GD患者的流行病资料,采用APGAR家庭功能问卷、生活事件量表(LES)和汉密尔顿抑郁量表(HAMD)进行评定,应用秩相关、直线相关、Logistic回归分析确定青年人初发GD并抑郁状态的危险因素。结果山东地区青年GD患者抑郁患病为54.6%。40~45岁组抑郁患病率高(P<0.05),女性30~40岁、40~45岁GD并抑郁患病率高于男性(P<0.05)。不同文化程度、经济收入、婚姻状况、家庭功能患病率比较差异有统计学意义(P<0.05)。回归分析结果显示,婚姻、年龄、FT3、TR-Ab、甲亢性眼病、生活事件是青年初发GD并抑郁的危险因素(P<0.05);家庭收入、TSH和家庭功能为青年初发GD并抑郁的保护因素(P<0.05)。结论山东地区青年人GD患者并抑郁的患病率高。离婚、年龄、FT3、TR-Ab、甲亢眼病、生活应激事件是青年人GD并抑郁的危险因素;家庭收入、TSH和家庭功能为保护因素。

Objective To explore the depressive state and its risk factors in young patients with incipient Graves Disease (GD) in Shandong province. Methods Epidemiological data of 1 158 young GD patients were collected and assessed with APGAR Family Function Scale, Life Event Scale(LES) and Hamilton Depression Scale(HAMD). Rank correlation, linear correlation and logistic regression analysis were used to determine risk factors for young GD patients with depressive state. Results,The prevalence rate of depression in young GD patients in Shandong province was 54.6%. The prevalence rate of depression in the 40~45 years old group was the highest among all the other age groups( P <0.05). The prevalence rates of depression in females in 30~40 years old group and 40~45 years old group were significantly higher than those in males( P < 0.05). There were significant differences in prevalence rates of depression in patients with different educational levels, incomes, marital status and family functions( P <0.05). The logistic regression analysis showed that marriage, age, FT 3, TR-Ab, Graves oculopathy and life events were risk factors for incipient GD with depression in young patients( P <0.05);family income, TSH and family function were protective factors( P <0.05). ConclusionThe prevalence rate of depression in young GD patients is high in Shandong province. Divorce, age, FT 3, TR-Ab, Graves oculopathy and life events are risk factors for GD with depression and family income, TSH and family function are protective factors.