中性粒细胞与淋巴细胞比值及超敏C反应蛋白与急性冠脉综合征病变程度的相关性研究

Correlation analysis between the ratio of neutrophils and lymphocytes,hs-CRP and the severity of acute coronary syndromes

目的探讨中性粒细胞与淋巴细胞比值(NLR)和超敏C反应蛋白(hs-CRP)与急性冠脉综合征(ACS)病变程度的相关性。方法2017年1月至2018年2月于该院诊治的ACS确诊患者125例纳入ACS组。同期诊治的具有胸痛、胸闷等可疑心绞痛症状,但行冠状动脉造影检查未见明显狭窄的患者60例纳入对照组。ACS患者按Gensini积分分为低值组、中值组和高值组。比较ASC组、对照组,以及不同Gensini积分组中性粒细胞、淋巴细胞、NLR及hs-CRP水平。结果 ACS组中性粒细胞、NLR、hs-CRP水平高于对照组(P<0.05)。不同Gensini积分组间中性粒细胞及NLR水平比较差异有统计学意义(P<0.05),随着Gensini积分增加,中性粒细胞及NLR水平逐渐升高;淋巴细胞与hs-CRP水平组间比较差异无统计学意义(P>0.05)。结论NLR、hs-CRP可能是ACS独立危险因素。NLR水平与ACS患者冠状动脉狭窄程度密切相关,可在一定程度上反映ACS病变程度。hs-CRP可能与ACS病变程度无相关性。

Objective To investigate the relationship between the ratio of neutrophil to lymphocyte(NLR),hypersensitive C-reactive protein(hs-CRP) and the severity of acute coronary syndromes(ACS). Methods From Jan.2017 to Feb.2018,125 patients with ACS were enrolled as ACS group.60 patients with suspicious angina pectoris symptoms such as chest pain and chest tightness but without obvious stenosis were enrolled as control gorup.The severity of coronary stenosis in ACS patients was evaluated according to Gensini score.According to GS score,ACS patients were divided into low level group,median level group and high level group.The levels of neutrophils,lymphocytes,NLR and hs-CRP were compared among the groups. Results The levels of neutrophils,NLR and hs-CRP in ACS group were significantly higher than control group( P <0.05).There were significantly differences in neutrophils and NLR values among the groups with different Gensini score( P <0.05).With the increasing of Gensini score,the levels of neutrophils and NLR increased gradually.There were no differences in lymphocyte and hs-CRP between any two groups( P > 0.05). Conclusion NLR and hs-CRP could be independent risk factors of ACS.The level of NLR might be closely related to the degree of coronary stenosis, which could be used to predict the degree of ACS lesion.hs-CRP might not be correlated with the severity of ACS.