白藜芦醇调控高雄激素诱导卵巢细胞乙酰化的研究进展

Research Advances in the Function of Resveratrol on Hyperandrogen-Induced Abnormal Acetylation of Ovarian Cells

多囊卵巢综合征(polycystic ovarian syndrome,PCOS)是一种以高雄激素表现为典型特征的育龄女性常见内分泌疾病,发病率高,异质性高,病因不明,现阶段临床仍采取对症治疗为主的策略。近年研究显示,PCOS患者卵巢细胞中组蛋白乙酰化修饰异常,与多种组蛋白乙酰转移酶和组蛋白去乙酰化酶的失衡有关。其中沉默信息调节因子1(silent information regulator 1,SIRT1)属组蛋白去乙酰化酶,可被白藜芦醇激活而降低相应组蛋白的乙酰化水平;且白藜芦醇可借助对抗氧化应激、调节雄激素和雌激素水平等途径缓解PCOS相关症状。综述去乙酰化酶SIRT1的激动剂白藜芦醇对高雄诱导的PCOS卵巢异常乙酰化的调控机制,以及白藜芦醇对卵巢功能的修复机制,展望白藜芦醇在PCOS临床治疗的潜在应用前景。

Characterized by hyperandrogen, polycystic ovary syndrome (PCOS) is a common endocrine dysfunction in women, with relatively high incidence as well as incurability. However, due to its high heterogeneity, there is no clear mechanism for its pathogenesis and thus the treatment keeps hovering at the stage of symptom-oriented medication. Positively, some results over the past few years have indicated that there were abnormal acetylation changes in ovarian cells of PCOS patients, which were originated from the imbalance of histone acetyltransferase and histone deacetylase. Silent information regulator 1 (SIRT1) is a histone deacetylase that can be activated by resveratrol to reduce the level of acetylation of the corresponding histones. Meanwhile, resveratrol can also rely on inhibition of oxidative stress, regulation of androgen and estrogen levels and other pathways to alleviate PCOS-related symptoms. This review focuses on the regulation mechanisms of resveratrol, an agonist of the deacetylase SIRT1, on the abnormal acetylation of ovarian in hyperandrogen-induced PCOS, and restoring mechanisms of ovarian dysfunctions by resveratrol, expecting for potential application of resveratrol in clinical treatment of PCOS.